Denosumab for treatment of bone metastases secondary to solid tumours: systematic review and network meta-analysis

John A Ford; Rob Jones; Andrew Elders; Clive Mulatero; Pamela Royle; Pawana Sharma; Fiona Stewart; Radha Todd; Graham Mowatt

doi:10.1016/j.ejca.2012.07.016

Denosumab for treatment of bone metastases secondary to solid tumours: systematic review and network meta-analysis

John A Ford, Rob Jones, Andrew Elders, Clive Mulatero, Pamela Royle, Pawana Sharma, Fiona Stewart, Radha Todd, Graham Mowatt

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

To evaluate the evidence for denosumab for the treatment of bone metastases secondary to solid tumours and, using a network meta-analysis, indirectly compare denosumab with bisphosphonates and best supportive care.

Original language	English
Pages (from-to)	416-30
Number of pages	15
Journal	European Journal of Cancer
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/j.ejca.2012.07.016
Publication status	Published - Jan 2013

Keywords

Antibodies, Monoclonal, Humanized
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Bone Neoplasms
Humans
Neoplasms
Survival Analysis

Access to Document

10.1016/j.ejca.2012.07.016

Cite this

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title = "Denosumab for treatment of bone metastases secondary to solid tumours: systematic review and network meta-analysis",

abstract = "To evaluate the evidence for denosumab for the treatment of bone metastases secondary to solid tumours and, using a network meta-analysis, indirectly compare denosumab with bisphosphonates and best supportive care.",

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AU - Royle, Pamela

AU - Sharma, Pawana

AU - Stewart, Fiona

AU - Todd, Radha

AU - Mowatt, Graham

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KW - Antineoplastic Combined Chemotherapy Protocols

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KW - Humans

KW - Neoplasms

KW - Survival Analysis

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