Depsipeptide Derivatives and their Therapeutic Use

Steven Joseph Shuttleworth (Inventor), A. Ganesan (Inventor), Alexander Richard Liam Cecil (Inventor), Thomas Hill (Inventor), Cyril Tomassi (Inventor), Franck Alexandre Silva (Inventor)

Research output: Patent


A compound of structure VII, VIII, IX or X wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 9 are the same or different and each represents an amino-acid side- chain moiety; each R 10 is the same or different and represents hydrogen or C 1 -C 6 alkyl, C 2 - C 6 alkenyl, C 2 -C 6 alkynyl or 5- or 6-membered aryl or heteroaryl; Pr is hydrogen or an alcohol protecting group; X1 and X2 _are the same or different and each represents a non-peptide moiety; and R 8 is a metallophile capable of binding with zinc in the active site of HDAC; with the proviso that X1 is not the group -CHR 1 -CH(OPr-)-CHR 9 -, wherein R 1 , Pr and R 9 are as defined above; and pharmaceutically acceptable salts thereof.
Original languageEnglish
Patent numberWO/2009/022182
Publication statusPublished - 2009

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