Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

R A Anderson; G R Ellis; Y Y Chirkov; A S Holmes; N Payne; D J Blackman; S K Jackson; M J Lewis; J D Horowitz; M P Frenneaux

doi:10.1016/S1388-9842(03)00038-2

Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

R A Anderson, G R Ellis, Y Y Chirkov, A S Holmes, N Payne, D J Blackman, S K Jackson, M J Lewis, J D Horowitz, M P Frenneaux

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p

Original language	English
Pages (from-to)	47-54
Number of pages	8
Journal	European Journal of Heart Failure
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/S1388-9842(03)00038-2
Publication status	Published - Jan 2004

Keywords

Adult
Age Factors
Aged
Angiotensin-Converting Enzyme Inhibitors
Case-Control Studies
Cell Culture Techniques
Female
Heart Failure
Humans
Male
Middle Aged
Nitric Oxide Donors
Nitroprusside
Oxidative Stress
Platelet Aggregation
Severity of Illness Index

Access to Document

10.1016/S1388-9842(03)00038-2

Cite this

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title = "Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure",

abstract = "Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p",

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author = "Anderson, {R A} and Ellis, {G R} and Chirkov, {Y Y} and Holmes, {A S} and N Payne and Blackman, {D J} and Jackson, {S K} and Lewis, {M J} and Horowitz, {J D} and Frenneaux, {M P}",

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AU - Anderson, R A

AU - Ellis, G R

AU - Chirkov, Y Y

AU - Holmes, A S

AU - Payne, N

AU - Blackman, D J

AU - Jackson, S K

AU - Lewis, M J

AU - Horowitz, J D

AU - Frenneaux, M P

PY - 2004/1

Y1 - 2004/1

N2 - Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p

AB - Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p

KW - Adult

KW - Age Factors

KW - Aged

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Case-Control Studies

KW - Cell Culture Techniques

KW - Female

KW - Heart Failure

KW - Humans

KW - Male

KW - Middle Aged

KW - Nitric Oxide Donors

KW - Nitroprusside

KW - Oxidative Stress

KW - Platelet Aggregation

KW - Severity of Illness Index

U2 - 10.1016/S1388-9842(03)00038-2

DO - 10.1016/S1388-9842(03)00038-2

M3 - Article

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VL - 6

SP - 47

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JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

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