Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

R A Anderson, G R Ellis, Y Y Chirkov, A S Holmes, N Payne, D J Blackman, S K Jackson, M J Lewis, J D Horowitz, M P Frenneaux

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28 Citations (Scopus)

Abstract

Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p
Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalEuropean Journal of Heart Failure
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Adult
  • Age Factors
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors
  • Case-Control Studies
  • Cell Culture Techniques
  • Female
  • Heart Failure
  • Humans
  • Male
  • Middle Aged
  • Nitric Oxide Donors
  • Nitroprusside
  • Oxidative Stress
  • Platelet Aggregation
  • Severity of Illness Index

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