Development of a LC-MS/MS method for the measurement of total fractionated urine metadrenalines and determination of a healthy population reference range

A Banks; John Dutton; K Phillipson; AS Davison

Development of a LC-MS/MS method for the measurement of total fractionated urine metadrenalines and determination of a healthy population reference range

A Banks, John Dutton, K Phillipson, AS Davison

Norwich Medical School

Research output: Contribution to conference › Poster › peer-review

Abstract

Phaeochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumours that arise from chromaffin tissue, typically in the adrenal medulla. They are characterised by the secretion of catecholamines and their methylated metabolites (metadrenaline, normetadrenaline and 3-methoxytyramine).
PCC/PGL pose a diagnostic dilemma to clinicians as they often present with non-specific symptoms (e.g. hypertension, sweating), or are found incidentally on imaging. Measurement of plasma or urine metadrenalines are recommended for the investigation of PCC as they offer superior diagnostic performance characteristics compared to catecholamines.

Original language	English
Publication status	Published - 2014
Event	EuroLabFocus - Liverpool, United Kingdom Duration: 7 Oct 2014 → 10 Oct 2014

Conference

Conference	EuroLabFocus
Country/Territory	United Kingdom
City	Liverpool
Period	7/10/14 → 10/10/14

Cite this

@conference{52eebb1b12214a1b8e041c8043a30d66,

title = "Development of a LC-MS/MS method for the measurement of total fractionated urine metadrenalines and determination of a healthy population reference range",

abstract = "Phaeochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumours that arise from chromaffin tissue, typically in the adrenal medulla. They are characterised by the secretion of catecholamines and their methylated metabolites (metadrenaline, normetadrenaline and 3-methoxytyramine).PCC/PGL pose a diagnostic dilemma to clinicians as they often present with non-specific symptoms (e.g. hypertension, sweating), or are found incidentally on imaging. Measurement of plasma or urine metadrenalines are recommended for the investigation of PCC as they offer superior diagnostic performance characteristics compared to catecholamines.",

author = "A Banks and John Dutton and K Phillipson and AS Davison",

year = "2014",

language = "English",

note = "EuroLabFocus ; Conference date: 07-10-2014 Through 10-10-2014",

}

TY - CONF

T1 - Development of a LC-MS/MS method for the measurement of total fractionated urine metadrenalines and determination of a healthy population reference range

AU - Banks, A

AU - Dutton, John

AU - Phillipson, K

AU - Davison, AS

PY - 2014

Y1 - 2014

N2 - Phaeochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumours that arise from chromaffin tissue, typically in the adrenal medulla. They are characterised by the secretion of catecholamines and their methylated metabolites (metadrenaline, normetadrenaline and 3-methoxytyramine).PCC/PGL pose a diagnostic dilemma to clinicians as they often present with non-specific symptoms (e.g. hypertension, sweating), or are found incidentally on imaging. Measurement of plasma or urine metadrenalines are recommended for the investigation of PCC as they offer superior diagnostic performance characteristics compared to catecholamines.

AB - Phaeochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumours that arise from chromaffin tissue, typically in the adrenal medulla. They are characterised by the secretion of catecholamines and their methylated metabolites (metadrenaline, normetadrenaline and 3-methoxytyramine).PCC/PGL pose a diagnostic dilemma to clinicians as they often present with non-specific symptoms (e.g. hypertension, sweating), or are found incidentally on imaging. Measurement of plasma or urine metadrenalines are recommended for the investigation of PCC as they offer superior diagnostic performance characteristics compared to catecholamines.

M3 - Poster

T2 - EuroLabFocus

Y2 - 7 October 2014 through 10 October 2014

ER -