Diastolic ventricular interaction: A possible mechanism for abnormal vascular responses during volume unloading in heart failure

John J. Atherton, Helen L. Thomson, Thomas D. Moore, Karen N. Wright, Gerry W. F. Muehle, Loretta E. Fitzpatrick, Michael P. Frenneaux

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34 Citations (Scopus)


Baroreflex dysfunction is common in chronic heart failure and contributes to the associated sympathoexcitation. Baroreceptor activity normally decreases during volume unloading, causing an increase in sympathetic outflow and resulting in forearm vasoconstriction. Some heart failure patients develop attenuated vasoconstriction or paradoxical vasodilation. The mechanism for this is unknown. We have recently demonstrated diastolic ventricular interaction in some patients with chronic heart failure as evidenced by increases in left ventricular (LV) end-diastolic volume in association with decreases in right ventricular (RV) volume during volume unloading. We reasoned that such an increase in LV volume, by increasing LV mechanoreceptor activity, would decrease sympathetic outflow and could therefore explain the abnormal vascular responses seen in such patients.
Original languageEnglish
Pages (from-to)4273-4279
Number of pages7
Issue number12
Publication statusPublished - 16 Dec 1997


  • Adult
  • Aged
  • Blood Vessels
  • Blood Volume
  • Cardiac Output, Low
  • Diastole
  • Female
  • Forearm
  • Humans
  • Lower Body Negative Pressure
  • Male
  • Middle Aged
  • Reference Values
  • Stroke Volume
  • Vascular Resistance
  • Ventricular Function, Left
  • Ventricular Function, Right

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