Abstract
In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3″)-3″-methylbutenyl-6-phenyl-pyran-2-one (2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus. Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 μg/ml, whereas compound 2 was inactive at a concentration of 512 μg/ml.
| Original language | English |
|---|---|
| Pages (from-to) | 403-406 |
| Number of pages | 4 |
| Journal | Phytochemistry |
| Volume | 70 |
| Issue number | 3 |
| Early online date | 4 Feb 2009 |
| DOIs | |
| Publication status | Published - Feb 2009 |
Keywords
- Antibacterial
- Dibenzofuran
- Guttiferae
- Hypericum choisianum
- Hypericum revolutum
- MDR
- MRSA
- Pyran-2-one
- Pyranone
- Staphylococcus aureus