Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum

Winnie Ka Po Shiu, Simon Gibbons

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3″)-3″-methylbutenyl-6-phenyl-pyran-2-one (2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus. Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 μg/ml, whereas compound 2 was inactive at a concentration of 512 μg/ml.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalPhytochemistry
Volume70
Issue number3
Early online date4 Feb 2009
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Antibacterial
  • Dibenzofuran
  • Guttiferae
  • Hypericum choisianum
  • Hypericum revolutum
  • MDR
  • MRSA
  • Pyran-2-one
  • Pyranone
  • Staphylococcus aureus

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