Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries

Punyanganie S A de Silva, Robert Luben, Subodha S Shrestha, Kay T Khaw, Andrew R Hart

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60 Citations (Scopus)


Dietary fatty acids may be involved in the etiology of ulcerative colitis (UC). Arachidonic acid (AA), an n-6 polyunsaturated fatty acid, is a precursor of the proinflammatory cytokines prostaglandin E2 and leukotriene B4, and its metabolism is competitively inhibited by oleic acid (OA). This study aimed to prospectively investigate whether AA is positively and OA is negatively associated with incident UC development, using data from 7-day food diaries.
Original languageEnglish
Pages (from-to)11-8
Number of pages8
JournalEuropean Journal of Gastroenterology & Hepatology
Issue number1
Publication statusPublished - Jan 2014

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