Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study

Yingchang Lu, Edith Jm Feskens, Martijn Et Dollé, Sandra Imholz, Wm Monique Verschuren, Michael Müller, Jolanda Ma Boer

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The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies.
Original languageEnglish
Pages (from-to)258-265
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Issue number1
Publication statusPublished - Jul 2010


  • 3' Untranslated Regions
  • Apolipoproteins B
  • Cholesterol
  • Cholesterol, Dietary
  • Cholesterol, HDL
  • Cohort Studies
  • Fatty Acid Desaturases
  • Genetic Variation
  • Genome, Human
  • Genotype
  • Humans
  • Multigene Family
  • Netherlands
  • Polymorphism, Single Nucleotide

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