Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study

Yingchang Lu; Edith Jm Feskens; Martijn Et Dollé; Sandra Imholz; Wm Monique Verschuren; Michael Müller; Jolanda Ma Boer

doi:10.3945/ajcn.2009.29130

Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study

Yingchang Lu
, Edith Jm Feskens
, Martijn Et Dollé
, Sandra Imholz
, Wm Monique Verschuren
, Michael Müller
, Jolanda Ma Boer

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies.

Original language	English
Pages (from-to)	258-265
Number of pages	8
Journal	American Journal of Clinical Nutrition
Volume	92
Issue number	1
DOIs	https://doi.org/10.3945/ajcn.2009.29130
Publication status	Published - Jul 2010

Keywords

3' Untranslated Regions
Apolipoproteins B
Cholesterol
Cholesterol, Dietary
Cholesterol, HDL
Cohort Studies
Fatty Acid Desaturases
Genetic Variation
Genome, Human
Genotype
Humans
Multigene Family
Netherlands
Polymorphism, Single Nucleotide

Access to Document

10.3945/ajcn.2009.29130

Cite this

Lu, Y., Feskens, E. J., Dollé, M. E., Imholz, S., Verschuren, W. M., Müller, M., & Boer, J. M. (2010). Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. American Journal of Clinical Nutrition, 92(1), 258-265. https://doi.org/10.3945/ajcn.2009.29130

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title = "Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study",

abstract = "The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies.",

keywords = "3' Untranslated Regions, Apolipoproteins B, Cholesterol, Cholesterol, Dietary, Cholesterol, HDL, Cohort Studies, Fatty Acid Desaturases, Genetic Variation, Genome, Human, Genotype, Humans, Multigene Family, Netherlands, Polymorphism, Single Nucleotide",

author = "Yingchang Lu and Feskens, \{Edith Jm\} and Doll{\'e}, \{Martijn Et\} and Sandra Imholz and Verschuren, \{Wm Monique\} and Michael M{\"u}ller and Boer, \{Jolanda Ma\}",

year = "2010",

month = jul,

doi = "10.3945/ajcn.2009.29130",

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volume = "92",

pages = "258--265",

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Lu, Y, Feskens, EJ, Dollé, ME, Imholz, S, Verschuren, WM, Müller, M & Boer, JM 2010, 'Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study', American Journal of Clinical Nutrition, vol. 92, no. 1, pp. 258-265. https://doi.org/10.3945/ajcn.2009.29130

Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. / Lu, Yingchang; Feskens, Edith Jm; Dollé, Martijn Et et al.
In: American Journal of Clinical Nutrition, Vol. 92, No. 1, 07.2010, p. 258-265.

Research output: Contribution to journal › Article › peer-review

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AU - Lu, Yingchang

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AU - Dollé, Martijn Et

AU - Imholz, Sandra

AU - Verschuren, Wm Monique

AU - Müller, Michael

AU - Boer, Jolanda Ma

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AB - The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies.

KW - 3' Untranslated Regions

KW - Apolipoproteins B

KW - Cholesterol

KW - Cholesterol, Dietary

KW - Cholesterol, HDL

KW - Cohort Studies

KW - Fatty Acid Desaturases

KW - Genetic Variation

KW - Genome, Human

KW - Genotype

KW - Humans

KW - Multigene Family

KW - Netherlands

KW - Polymorphism, Single Nucleotide

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EP - 265

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

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