Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

Sneha John; Robert Luben; Subodha Shakya Shrestha; Ailsa Welch; Kay-Tee Khaw; Andrew R Hart

doi:10.1097/MEG.0b013e3283352d05

Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

Sneha John, Robert Luben, Subodha Shakya Shrestha, Ailsa Welch, Kay-Tee Khaw, Andrew R Hart

Research output: Contribution to journal › Article › peer-review

162 Citations (Scopus)

Abstract

The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.

Original language	English
Pages (from-to)	602-606
Number of pages	5
Journal	European Journal of Gastroenterology & Hepatology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1097/MEG.0b013e3283352d05
Publication status	Published - May 2010

Keywords

Aged
Cohort Studies
Colitis, Ulcerative
Databases, Factual
Diet Records
Dietary Fats, Unsaturated
Dietary Supplements
Docosahexaenoic Acids
Eicosapentaenoic Acid
Fatty Acids, Omega-3
Fatty Acids, Unsaturated
Female
Fish Oils
Follow-Up Studies
Great Britain
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk Factors

Access to Document

10.1097/MEG.0b013e3283352d05

Cite this

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title = "Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study",

abstract = "The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.",

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author = "Sneha John and Robert Luben and Shrestha, {Subodha Shakya} and Ailsa Welch and Kay-Tee Khaw and Hart, {Andrew R}",

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AU - John, Sneha

AU - Luben, Robert

AU - Shrestha, Subodha Shakya

AU - Welch, Ailsa

AU - Khaw, Kay-Tee

AU - Hart, Andrew R

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KW - Incidence

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