Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

Sneha John, Robert Luben, Subodha Shakya Shrestha, Ailsa Welch, Kay-Tee Khaw, Andrew R Hart

Research output: Contribution to journalArticlepeer-review

161 Citations (Scopus)


The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.
Original languageEnglish
Pages (from-to)602-606
Number of pages5
JournalEuropean Journal of Gastroenterology & Hepatology
Issue number5
Publication statusPublished - May 2010


  • Aged
  • Cohort Studies
  • Colitis, Ulcerative
  • Databases, Factual
  • Diet Records
  • Dietary Fats, Unsaturated
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
  • Fatty Acids, Omega-3
  • Fatty Acids, Unsaturated
  • Female
  • Fish Oils
  • Follow-Up Studies
  • Great Britain
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors

Cite this