Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

Sneha John; Robert Luben; Subodha Shakya Shrestha; Ailsa Welch; Kay-Tee Khaw; Andrew R Hart

doi:10.1097/MEG.0b013e3283352d05

Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

Sneha John, Robert Luben, Subodha Shakya Shrestha, Ailsa Welch, Kay-Tee Khaw, Andrew R Hart

Research output: Contribution to journal › Article › peer-review

175 Citations (Scopus)

Abstract

The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.

Original language	English
Pages (from-to)	602-606
Number of pages	5
Journal	European Journal of Gastroenterology & Hepatology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1097/MEG.0b013e3283352d05
Publication status	Published - May 2010

Keywords

Aged
Cohort Studies
Colitis, Ulcerative
Databases, Factual
Diet Records
Dietary Fats, Unsaturated
Dietary Supplements
Docosahexaenoic Acids
Eicosapentaenoic Acid
Fatty Acids, Omega-3
Fatty Acids, Unsaturated
Female
Fish Oils
Follow-Up Studies
Great Britain
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk Factors

Access to Document

10.1097/MEG.0b013e3283352d05

Cite this

@article{8839c9f36e724f06b7ac72a46fdea834,

title = "Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study",

abstract = "The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.",

keywords = "Aged, Cohort Studies, Colitis, Ulcerative, Databases, Factual, Diet Records, Dietary Fats, Unsaturated, Dietary Supplements, Docosahexaenoic Acids, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Fatty Acids, Unsaturated, Female, Fish Oils, Follow-Up Studies, Great Britain, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk Factors",

author = "Sneha John and Robert Luben and Shrestha, {Subodha Shakya} and Ailsa Welch and Kay-Tee Khaw and Hart, {Andrew R}",

year = "2010",

month = may,

doi = "10.1097/MEG.0b013e3283352d05",

language = "English",

volume = "22",

pages = "602--606",

journal = "European Journal of Gastroenterology & Hepatology",

issn = "0954-691X",

publisher = "Lippincott, Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

AU - John, Sneha

AU - Luben, Robert

AU - Shrestha, Subodha Shakya

AU - Welch, Ailsa

AU - Khaw, Kay-Tee

AU - Hart, Andrew R

PY - 2010/5

Y1 - 2010/5

N2 - The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.

AB - The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC.

KW - Aged

KW - Cohort Studies

KW - Colitis, Ulcerative

KW - Databases, Factual

KW - Diet Records

KW - Dietary Fats, Unsaturated

KW - Dietary Supplements

KW - Docosahexaenoic Acids

KW - Eicosapentaenoic Acid

KW - Fatty Acids, Omega-3

KW - Fatty Acids, Unsaturated

KW - Female

KW - Fish Oils

KW - Follow-Up Studies

KW - Great Britain

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1097/MEG.0b013e3283352d05

DO - 10.1097/MEG.0b013e3283352d05

M3 - Article

C2 - 20216220

SN - 0954-691X

VL - 22

SP - 602

EP - 606

JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

IS - 5

ER -