Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report

Timothy Ellam; Martin Wilkie; Janet Chamberlain; David Crossman; Richard Eastell; Sheila Francis; Timothy J A Chico

doi:10.1161/ATVBAHA.111.231001

Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report

Timothy Ellam, Martin Wilkie, Janet Chamberlain, David Crossman, Richard Eastell, Sheila Francis, Timothy J A Chico

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Epidemiological studies link higher serum phosphate and the phosphatonin fibroblast growth factor 23 with cardiovascular events and atheroma, and they link lower serum phosphate with insulin resistance and the metabolic syndrome. We investigated whether manipulating dietary phosphate influences atherogenesis or insulin sensitivity in mice.

Original language	English
Pages (from-to)	1988-90
Number of pages	3
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	31
Issue number	9
DOIs	https://doi.org/10.1161/ATVBAHA.111.231001
Publication status	Published - Sep 2011

Keywords

Adiposity
Animals
Apolipoproteins E
Atherosclerosis
Fatty Liver
Insulin Resistance
Male
Mice
Mice, Knockout
Phosphates

Access to Document

10.1161/ATVBAHA.111.231001

Cite this

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title = "Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report",

abstract = "Epidemiological studies link higher serum phosphate and the phosphatonin fibroblast growth factor 23 with cardiovascular events and atheroma, and they link lower serum phosphate with insulin resistance and the metabolic syndrome. We investigated whether manipulating dietary phosphate influences atherogenesis or insulin sensitivity in mice.",

keywords = "Adiposity, Animals, Apolipoproteins E, Atherosclerosis, Fatty Liver, Insulin Resistance, Male, Mice, Mice, Knockout, Phosphates",

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AU - Ellam, Timothy

AU - Wilkie, Martin

AU - Chamberlain, Janet

AU - Crossman, David

AU - Eastell, Richard

AU - Francis, Sheila

AU - Chico, Timothy J A

PY - 2011/9

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N2 - Epidemiological studies link higher serum phosphate and the phosphatonin fibroblast growth factor 23 with cardiovascular events and atheroma, and they link lower serum phosphate with insulin resistance and the metabolic syndrome. We investigated whether manipulating dietary phosphate influences atherogenesis or insulin sensitivity in mice.

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KW - Adiposity

KW - Animals

KW - Apolipoproteins E

KW - Atherosclerosis

KW - Fatty Liver

KW - Insulin Resistance

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Phosphates

U2 - 10.1161/ATVBAHA.111.231001

DO - 10.1161/ATVBAHA.111.231001

M3 - Article

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VL - 31

SP - 1988

EP - 1990

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

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