Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report

Timothy Ellam, Martin Wilkie, Janet Chamberlain, David Crossman, Richard Eastell, Sheila Francis, Timothy J A Chico

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Epidemiological studies link higher serum phosphate and the phosphatonin fibroblast growth factor 23 with cardiovascular events and atheroma, and they link lower serum phosphate with insulin resistance and the metabolic syndrome. We investigated whether manipulating dietary phosphate influences atherogenesis or insulin sensitivity in mice.
Original languageEnglish
Pages (from-to)1988-90
Number of pages3
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Adiposity
  • Animals
  • Apolipoproteins E
  • Atherosclerosis
  • Fatty Liver
  • Insulin Resistance
  • Male
  • Mice
  • Mice, Knockout
  • Phosphates

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