TY - JOUR
T1 - Dietary polyphenols in the aetiology of Crohn's disease and ulcerative colitis - A multicenter European prospective cohort study (EPIC)
AU - Lu, Yunxia
AU - Zamora-Ros, Raul
AU - Chan, Simon
AU - Cross, Amanda J.
AU - Ward, Heather
AU - Jakszyn, Paula
AU - Luben, Robert
AU - Opstelten, Jorrit L.
AU - Oldenburg, Bas
AU - Hallmans, Göran
AU - Karling, Pontus
AU - Grip, Olof
AU - Key, Timothy
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Overvad, Kim
AU - Palli, Domenico
AU - Masala, Giovanna
AU - Khaw, Kay Tee
AU - Racine, Antoine
AU - Carbonnel, Franck
AU - Boutron-Ruault, Marie Christine
AU - Andersen, Vibeke
AU - Olsen, Anja
AU - Tjonneland, Anne
AU - Kaaks, Rudolf
AU - Tumino, Rosario
AU - Trichopoulou, Antonia
AU - Scalbert, Augustin
AU - Riboli, Elio
AU - Hart, Andrew R.
N1 - Publisher Copyright:
© 2017 Oxford University Press. All rights reserved.
PY - 2017/12
Y1 - 2017/12
N2 - Background: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. Methods: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn’s diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case–control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC. Results: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend ¼ 0.17) or UC (P trend ¼ 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile ¼ 0.33; 95% confidence interval, 0.15–0.69) and there was an inverse trend across quartiles (P ¼ 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile ¼ 0.40; 95% confidence interval, 0.20–0.82) with an inverse trend across quartiles (P ¼ 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance. Conclusions: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
AB - Background: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. Methods: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn’s diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case–control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC. Results: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend ¼ 0.17) or UC (P trend ¼ 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile ¼ 0.33; 95% confidence interval, 0.15–0.69) and there was an inverse trend across quartiles (P ¼ 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile ¼ 0.40; 95% confidence interval, 0.20–0.82) with an inverse trend across quartiles (P ¼ 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance. Conclusions: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
KW - antioxidants
KW - Crohn's diseases
KW - polyphenols
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85047559286&partnerID=8YFLogxK
U2 - 10.1097/mib.0000000000001108
DO - 10.1097/mib.0000000000001108
M3 - Article
C2 - 28837515
VL - 23
SP - 2072
EP - 2082
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1078-0998
IS - 12
ER -