Differential expression of cell adhesion molecules within inflamed ileal pouch mucosa: relationship to recruited cell subtypes

P D Thomas, A Forbes, A B Price, R J Nicholls, P J Ciclitira

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10 Citations (Scopus)

Abstract

Endothelial-bound cell adhesion molecules are important in recruiting inflammatory cells to the mucosa in inflammatory bowel disease (IBD). Little is known of the expression of these molecules in relation to the recruitment of particular cell subtypes in the early course of mucosal inflammation. We therefore studied the expression of several adhesion molecules to examine their potential correlation with the cellular infiltrate in the inflamed ileal pouch, a possible disease model for ulcerative colitis.
Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalEuropean Journal of Gastroenterology & Hepatology
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2002

Keywords

  • Adenomatous Polyposis Coli
  • Adult
  • Aged
  • Antigens, CD15
  • Cell Movement
  • E-Selectin
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulins
  • Intercellular Adhesion Molecule-1
  • Intestinal Mucosa
  • Male
  • Middle Aged
  • Mucoproteins
  • Neutrophil Infiltration
  • Receptors, Lymphocyte Homing
  • Up-Regulation
  • Vascular Cell Adhesion Molecule-1

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