Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia

Muireann Irish, Andrew Graham, Kim S. Graham, John R. Hodges, Michael Hornberger

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Episodic memory has recently been shown to be impaired in the behavioral variant of frontotemporal dementia (bvFTD) when so-called non-progressive cases are excluded. Such non-progressive cases present with the behavioral features of bvFTD, but show no evidence of cognitive decline over time. To date, evidence regarding episodic memory performance in bvFTD subgroups on more stringent tasks is lacking. We investigated temporal and spatial source memory in progressive (n = 7) versus non-progressive (n = 12) bvFTD. BvFTD cases were retrospectively classified based on general cognitive decline on the Addenbrooke's Cognitive Examination Revised, and the presence of atrophy on structural neuroimaging, over 3 years following diagnosis. Progressors showed impaired temporal and spatial source retrieval. Non-progressors displayed temporal source deficits only. These differential source memory profiles point to the variability of episodic memory performance in bvFTD, and underscore the importance of differential diagnosis of bvFTD subgroups using longitudinal and neuroimaging data.

Original languageEnglish
Pages (from-to)338-347
Number of pages10
JournalArchives of Clinical Neuropsychology
Issue number3
Early online date13 Mar 2012
Publication statusPublished - May 2012


  • Differential diagnosis
  • Episodic memory
  • Frontotemporal dementia
  • Source memory

Cite this