Direct C-H/C-X coupling methodologies mediated by Pd/Cu or Cu: An examination of the synthetic applications and mechanistic findings

Sara De Ornellas, Thomas E. Storr, Thomas J. Williams, Christoph G. Baumann, Ian J. S. Fairlamb

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Organocopper chemistry has long been known to be powerful synthetic methodology leading to the generation of C-C, C-O, C-N, C-S and C-X bonds. Advances in catalytic and stoichiometric organometallic reactions for the formation of C-C bonds from unfunctionalised arenes, e.g. by activation-functionalisation of a C-H bond, provides diverse and applicable reaction conditions for direct functionalisation. This review covers the background, applications and recent advances made in the area of aromatic C-X/C-H-bond couplings promoted by copper and copper/palladium mixed systems. The efficacy and scope of these reactions are discussed and the different methodologies are placed into context. Mechanistic considerations and evidence are highlighted at appropriate junctures in the review.
Original languageEnglish
Pages (from-to)79-101
Number of pages23
JournalCurrent Organic Synthesis
Issue number1
Publication statusPublished - 1 Feb 2011

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