Discovery and synthesis of Boletopsins 13 and 14, brominated fungal metabolites of terrestrial origin

Andrew M. Beekman, Stewart W. Wossa, Oromo Kevo, Paul Ma, Russell A. Barrow

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    10 Citations (Scopus)

    Abstract

    Here we report the discovery and synthesis of complex polybrominated p-terphenyl ethers isolated from a mushroom (Boletopsis sp.) used as a traditional medicine by the Kiovi people in the highlands of Papua New Guinea. Boletopsins 13 and 14 represent the first report of polybrominated fungal metabolites to be produced by a terrestrial fungus. The synthetic method employs 2,4,4,6-tetrabromo-2,5-cyclohexadienone to achieve selective polybromination of the extended aromatic system in a selective and sequential manner.
    Original languageEnglish
    Pages (from-to)2133-2135
    Number of pages3
    JournalJournal of Natural Products
    Volume78
    Issue number8
    Early online date24 Jul 2015
    DOIs
    Publication statusPublished - 28 Aug 2015

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