Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation

Adam D. Celiz, James G.W. Smith, Asha K. Patel, Andrew L. Hook, Divya Rajamohan, Vinoj T. George, Luke Flatt, Minal J. Patel, Vidana C. Epa, Taranjit Singh, Robert Langer, Daniel G. Anderson, Nicholas D. Allen, David C. Hay, David A. Winkler, David A. Barrett, Martyn C. Davies, Lorraine E. Young, Chris Denning, Morgan R. Alexander

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Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.
Original languageEnglish
Pages (from-to)4006-4012
Number of pages7
JournalAdvanced Materials
Volume27
Issue number27
Early online date1 Jun 2015
DOIs
Publication statusPublished - 15 Jul 2015

Keywords

  • high throughput
  • human pluripotent stem cells
  • materials discovery
  • polymer microarrays
  • stem cell differentiation

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