Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation

Luciano I. Mariano; Claire O'Callaghan; Henrique C. Guimarães; Leandro B. Gambogi; Thaís B. L. da Silva; Mônica S. Yassuda; Juliana S. Amaral; Paulo Caramelli; Michael Hornberger; Antônio L. Teixeira; Leonardo C. de Souza

doi:10.1017/S1355617719000973

Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation

Luciano I. Mariano, Claire O'Callaghan, Henrique C. Guimarães, Leandro B. Gambogi, Thaís B. L. da Silva, Mônica S. Yassuda, Juliana S. Amaral, Paulo Caramelli, Michael Hornberger, Antônio L. Teixeira, Leonardo C. de Souza

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE: Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer's disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD.

METHODS: Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11).

RESULTS: bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001).

CONCLUSIONS: Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.

Original language	English
Pages (from-to)	163-171
Number of pages	9
Journal	Journal of the International Neuropsychological Society
Volume	26
Issue number	2
Early online date	23 Sep 2019
DOIs	https://doi.org/10.1017/S1355617719000973
Publication status	Published - Feb 2020

Keywords

Alzheimer's disease
Behavioural variant Frontotemporal Dementia
Delay discounting
Executive function
Impulsivity
Inhibitory control
BATTERY
APATHY
REWARDS
MEMORY PROFILES
IMPULSIVITY
VARIANT
INVENTORY
INHIBITORY DYSFUNCTION
DIAGNOSTIC-CRITERIA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mariano, L. I., O'Callaghan, C., Guimarães, H. C., Gambogi, L. B., da Silva, T. B. L., Yassuda, M. S., Amaral, J. S., Caramelli, P., Hornberger, M., Teixeira, A. L., & de Souza, L. C. (2020). Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation. Journal of the International Neuropsychological Society, 26(2), 163-171. https://doi.org/10.1017/S1355617719000973

@article{771ec6c3a34147f9bd1636dae556f9fa,

title = "Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation",

abstract = "OBJECTIVE: Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer's disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD.METHODS: Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11).RESULTS: bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001).CONCLUSIONS: Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.",

keywords = "Alzheimer's disease, Behavioural variant Frontotemporal Dementia, Delay discounting, Executive function, Impulsivity, Inhibitory control, BATTERY, APATHY, REWARDS, MEMORY PROFILES, IMPULSIVITY, VARIANT, INVENTORY, INHIBITORY DYSFUNCTION, DIAGNOSTIC-CRITERIA",

author = "Mariano, {Luciano I.} and Claire O'Callaghan and Guimar{\~a}es, {Henrique C.} and Gambogi, {Leandro B.} and {da Silva}, {Tha{\'i}s B. L.} and Yassuda, {M{\^o}nica S.} and Amaral, {Juliana S.} and Paulo Caramelli and Michael Hornberger and Teixeira, {Ant{\^o}nio L.} and {de Souza}, {Leonardo C.}",

year = "2020",

month = feb,

doi = "10.1017/S1355617719000973",

language = "English",

volume = "26",

pages = "163--171",

journal = "Journal of the International Neuropsychological Society",

issn = "1355-6177",

publisher = "Cambridge University Press",

number = "2",

}

Mariano, LI, O'Callaghan, C, Guimarães, HC, Gambogi, LB, da Silva, TBL, Yassuda, MS, Amaral, JS, Caramelli, P, Hornberger, M, Teixeira, AL & de Souza, LC 2020, 'Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation', Journal of the International Neuropsychological Society, vol. 26, no. 2, pp. 163-171. https://doi.org/10.1017/S1355617719000973

TY - JOUR

T1 - Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation

AU - Mariano, Luciano I.

AU - O'Callaghan, Claire

AU - Guimarães, Henrique C.

AU - Gambogi, Leandro B.

AU - da Silva, Thaís B. L.

AU - Yassuda, Mônica S.

AU - Amaral, Juliana S.

AU - Caramelli, Paulo

AU - Hornberger, Michael

AU - Teixeira, Antônio L.

AU - de Souza, Leonardo C.

PY - 2020/2

Y1 - 2020/2

N2 - OBJECTIVE: Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer's disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD.METHODS: Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11).RESULTS: bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001).CONCLUSIONS: Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.

AB - OBJECTIVE: Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer's disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD.METHODS: Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11).RESULTS: bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001).CONCLUSIONS: Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.

KW - Alzheimer's disease

KW - Behavioural variant Frontotemporal Dementia

KW - Delay discounting

KW - Executive function

KW - Impulsivity

KW - Inhibitory control

KW - BATTERY

KW - APATHY

KW - REWARDS

KW - MEMORY PROFILES

KW - IMPULSIVITY

KW - VARIANT

KW - INVENTORY

KW - INHIBITORY DYSFUNCTION

KW - DIAGNOSTIC-CRITERIA

UR - http://www.scopus.com/inward/record.url?scp=85072684901&partnerID=8YFLogxK

U2 - 10.1017/S1355617719000973

DO - 10.1017/S1355617719000973

M3 - Article

C2 - 31543087

VL - 26

SP - 163

EP - 171

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 2

ER -

Disinhibition in frontotemporal dementia and Alzheimer's disease: A neuropsychological and behavioural investigation

Abstract

Keywords

UN SDGs

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Michael Hornberger

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