Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts

A. E. Mather; S. W. J. Reid; D. J. Maskell; J. Parkhill; M. C. Fookes; S. R. Harris; D. J. Brown; J. E. Coia; M. R. Mulvey; M. W. Gilmour; L. Petrovska; E. De Pinna; M. Kuroda; M. Akiba; H. Izumiya; T. R. Connor; M. A. Suchard; P. Lemey; D. J. Mellor; D. T. Haydon; N. R. Thomson

doi:10.1126/science.1240578

Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts

A. E. Mather, S. W. J. Reid, D. J. Maskell, J. Parkhill, M. C. Fookes, S. R. Harris, D. J. Brown, J. E. Coia, M. R. Mulvey, M. W. Gilmour, L. Petrovska, E. De Pinna, M. Kuroda, M. Akiba, H. Izumiya, T. R. Connor, M. A. Suchard, P. Lemey, D. J. Mellor, D. T. HaydonN. R. Thomson

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263 Citations (Scopus)

Abstract

The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.

Original language	English
Pages (from-to)	1514-1517
Number of pages	4
Journal	Science
Volume	341
Issue number	6153
DOIs	https://doi.org/10.1126/science.1240578
Publication status	Published - 2013

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Mather, A. E., Reid, S. W. J., Maskell, D. J., Parkhill, J., Fookes, M. C., Harris, S. R., Brown, D. J., Coia, J. E., Mulvey, M. R., Gilmour, M. W., Petrovska, L., De Pinna, E., Kuroda, M., Akiba, M., Izumiya, H., Connor, T. R., Suchard, M. A., Lemey, P., Mellor, D. J., ... Thomson, N. R. (2013). Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts. Science, 341(6153), 1514-1517. https://doi.org/10.1126/science.1240578

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title = "Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts",

abstract = "The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.",

author = "Mather, {A. E.} and Reid, {S. W. J.} and Maskell, {D. J.} and J. Parkhill and Fookes, {M. C.} and Harris, {S. R.} and Brown, {D. J.} and Coia, {J. E.} and Mulvey, {M. R.} and Gilmour, {M. W.} and L. Petrovska and {De Pinna}, E. and M. Kuroda and M. Akiba and H. Izumiya and Connor, {T. R.} and Suchard, {M. A.} and P. Lemey and Mellor, {D. J.} and Haydon, {D. T.} and Thomson, {N. R.}",

year = "2013",

doi = "10.1126/science.1240578",

language = "English",

volume = "341",

pages = "1514--1517",

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Mather, AE, Reid, SWJ, Maskell, DJ, Parkhill, J, Fookes, MC, Harris, SR, Brown, DJ, Coia, JE, Mulvey, MR, Gilmour, MW, Petrovska, L, De Pinna, E, Kuroda, M, Akiba, M, Izumiya, H, Connor, TR, Suchard, MA, Lemey, P, Mellor, DJ, Haydon, DT & Thomson, NR 2013, 'Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts', Science, vol. 341, no. 6153, pp. 1514-1517. https://doi.org/10.1126/science.1240578

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T1 - Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts

AU - Mather, A. E.

AU - Reid, S. W. J.

AU - Maskell, D. J.

AU - Parkhill, J.

AU - Fookes, M. C.

AU - Harris, S. R.

AU - Brown, D. J.

AU - Coia, J. E.

AU - Mulvey, M. R.

AU - Gilmour, M. W.

AU - Petrovska, L.

AU - De Pinna, E.

AU - Kuroda, M.

AU - Akiba, M.

AU - Izumiya, H.

AU - Connor, T. R.

AU - Suchard, M. A.

AU - Lemey, P.

AU - Mellor, D. J.

AU - Haydon, D. T.

AU - Thomson, N. R.

PY - 2013

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N2 - The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.

AB - The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.

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JF - Science

SN - 0036-8075

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ER -

Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts

Abstract

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