Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease

Clive M Onnie; Sheila A Fisher; Natalie J Prescott; Muddassar M Mirza; Peter Green; Jeremy Sanderson; Alastair Forbes; Cathryn M Lewis; Christopher G Mathew

doi:10.1097/MEG.0b013e3282f1622b

Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease

Clive M Onnie, Sheila A Fisher, Natalie J Prescott, Muddassar M Mirza, Peter Green, Jeremy Sanderson, Alastair Forbes, Cathryn M Lewis, Christopher G Mathew

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Genetic variants at the CARD15 and IBD5 loci are strongly associated with Crohn's disease (CD), but evidence of the effect of these variants on the clinical expression of CD is conflicting and has often been hampered by small sample sizes. We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD.

Original language	English
Pages (from-to)	37-45
Number of pages	9
Journal	European Journal of Gastroenterology & Hepatology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1097/MEG.0b013e3282f1622b
Publication status	Published - Jan 2008

Keywords

Adolescent
Adult
Age of Onset
Child
Crohn Disease
Female
Gene Frequency
Genotype
Granuloma
Humans
Ileitis
Linkage Disequilibrium
Male
Mutation
Nod2 Signaling Adaptor Protein
Phenotype
Postoperative Complications
Recurrence

Access to Document

10.1097/MEG.0b013e3282f1622b

Cite this

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title = "Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease",

abstract = "Genetic variants at the CARD15 and IBD5 loci are strongly associated with Crohn's disease (CD), but evidence of the effect of these variants on the clinical expression of CD is conflicting and has often been hampered by small sample sizes. We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD.",

keywords = "Adolescent, Adult, Age of Onset, Child, Crohn Disease, Female, Gene Frequency, Genotype, Granuloma, Humans, Ileitis, Linkage Disequilibrium, Male, Mutation, Nod2 Signaling Adaptor Protein, Phenotype, Postoperative Complications, Recurrence",

author = "Onnie, {Clive M} and Fisher, {Sheila A} and Prescott, {Natalie J} and Mirza, {Muddassar M} and Peter Green and Jeremy Sanderson and Alastair Forbes and Lewis, {Cathryn M} and Mathew, {Christopher G}",

year = "2008",

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doi = "10.1097/MEG.0b013e3282f1622b",

language = "English",

volume = "20",

pages = "37--45",

journal = "European Journal of Gastroenterology & Hepatology",

issn = "0954-691X",

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T1 - Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease

AU - Onnie, Clive M

AU - Fisher, Sheila A

AU - Prescott, Natalie J

AU - Mirza, Muddassar M

AU - Green, Peter

AU - Sanderson, Jeremy

AU - Forbes, Alastair

AU - Lewis, Cathryn M

AU - Mathew, Christopher G

PY - 2008/1

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N2 - Genetic variants at the CARD15 and IBD5 loci are strongly associated with Crohn's disease (CD), but evidence of the effect of these variants on the clinical expression of CD is conflicting and has often been hampered by small sample sizes. We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD.

AB - Genetic variants at the CARD15 and IBD5 loci are strongly associated with Crohn's disease (CD), but evidence of the effect of these variants on the clinical expression of CD is conflicting and has often been hampered by small sample sizes. We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Child

KW - Crohn Disease

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Granuloma

KW - Humans

KW - Ileitis

KW - Linkage Disequilibrium

KW - Male

KW - Mutation

KW - Nod2 Signaling Adaptor Protein

KW - Phenotype

KW - Postoperative Complications

KW - Recurrence

U2 - 10.1097/MEG.0b013e3282f1622b

DO - 10.1097/MEG.0b013e3282f1622b

M3 - Article

C2 - 18090989

VL - 20

SP - 37

EP - 45

JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

SN - 0954-691X

IS - 1

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