Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease

Clive M Onnie, Sheila A Fisher, Natalie J Prescott, Muddassar M Mirza, Peter Green, Jeremy Sanderson, Alastair Forbes, Cathryn M Lewis, Christopher G Mathew

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28 Citations (Scopus)


Genetic variants at the CARD15 and IBD5 loci are strongly associated with Crohn's disease (CD), but evidence of the effect of these variants on the clinical expression of CD is conflicting and has often been hampered by small sample sizes. We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD.
Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalEuropean Journal of Gastroenterology & Hepatology
Issue number1
Publication statusPublished - Jan 2008


  • Adolescent
  • Adult
  • Age of Onset
  • Child
  • Crohn Disease
  • Female
  • Gene Frequency
  • Genotype
  • Granuloma
  • Humans
  • Ileitis
  • Linkage Disequilibrium
  • Male
  • Mutation
  • Nod2 Signaling Adaptor Protein
  • Phenotype
  • Postoperative Complications
  • Recurrence

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