DNA G-quadruplex and i-motif structure formation is interdependent in human cells

Jessica J. King, Kelly L. Irving, Cameron W. Evans, Rupesh Chikhale, Rouven Becker, Chris Morris, Cristian D. Peña Martinez, Peter Schofield, Daniel Christ, Laurence H. Hurley, Zoe Waller, K. Swaminathan Iyer, Nicole M. Smith

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Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.

Original languageEnglish
Pages (from-to)20600–20604
Number of pages5
JournalJournal of the American Chemical Society
Issue number49
Early online date30 Nov 2020
Publication statusPublished - 9 Dec 2020

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