DNA replication licensing factor

James P. J. Chong; J. Julian Blow

doi:10.1007/978-1-4615-5873-6_8

DNA replication licensing factor

James P. J. Chong, J. Julian Blow

Vice-Chancellor's Office

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

14 Citations (Scopus)

Abstract

DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

Original language	English
Title of host publication	Progress in Cell Cycle Research
Publisher	Plenum Press
Chapter	8
Pages	83-90
Number of pages	8
Volume	2
DOIs	https://doi.org/10.1007/978-1-4615-5873-6_8
Publication status	Published - 1996

Publication series

Name	Progress in Cell Cycle Research
Publisher	Kluwer Academic/ Plenum Press
ISSN (Print)	1087-2957

Access to Document

10.1007/978-1-4615-5873-6_8

Cite this

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title = "DNA replication licensing factor",

abstract = "DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.",

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TY - CHAP

T1 - DNA replication licensing factor

AU - Chong, James P. J.

AU - Blow, J. Julian

PY - 1996

Y1 - 1996

N2 - DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

AB - DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

U2 - 10.1007/978-1-4615-5873-6_8

DO - 10.1007/978-1-4615-5873-6_8

M3 - Chapter (peer-reviewed)

VL - 2

T3 - Progress in Cell Cycle Research

SP - 83

EP - 90

BT - Progress in Cell Cycle Research

PB - Plenum Press

ER -