DNA Structure and Replication

Richard Bowater

DNA Structure and Replication

Research output: Non-textual form › Digital or Visual Products

Abstract

About the Course: In this lecture, Professor Richard Bowater (University of East Anglia) talks about DNA, its structure, its replication and how it can code for proteins. To do so, we: (i) discuss the microscopic structure of DNA, looking at what each monomer (nucleotide) is made of; before (ii) understanding the history of its discovery and the macroscopic structure; following onto (iii) DNA polymerase and its role in DNA synthesis; which then goes on to (iv) the coding and non-coding sections of DNA and how four nucleotides code for 20 amino acids; before (v) diving into the step-by-step process of how new nucleotides are added to DNA; and then finally (vi) understanding how DNA can be mutated and damaged, and some of the implications this can have on the proteins it codes for.

About the Lecturer: Having trained as a biochemist, Professor Richard Bowater's research interests broadened out to encompass methodologies that involve biophysical chemistry, microbiology, molecular biology and bioinformatics. His research focuses on macromolecular interactions of bacterial DNA repair proteins, particularly DNA and RNA ligases, with experiments performed in vitro or in bacterial model organisms. His areas of expertise include the relationship of genetic instabilities to human diseases; trinucleotide (triplet) repeat expansions and human neurodegenerative disorders; DNA repair processes; and protein-protein and protein-DNA interactions.

Original language	English
Publisher	MASSOLIT
Media of output	Online
Size	6 videos, approx 1 hour
Publication status	Published - 5 Sep 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://www.massolit.io/courses/dna-structure-and-replication

Cite this

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AB - About the Course: In this lecture, Professor Richard Bowater (University of East Anglia) talks about DNA, its structure, its replication and how it can code for proteins. To do so, we: (i) discuss the microscopic structure of DNA, looking at what each monomer (nucleotide) is made of; before (ii) understanding the history of its discovery and the macroscopic structure; following onto (iii) DNA polymerase and its role in DNA synthesis; which then goes on to (iv) the coding and non-coding sections of DNA and how four nucleotides code for 20 amino acids; before (v) diving into the step-by-step process of how new nucleotides are added to DNA; and then finally (vi) understanding how DNA can be mutated and damaged, and some of the implications this can have on the proteins it codes for. About the Lecturer: Having trained as a biochemist, Professor Richard Bowater's research interests broadened out to encompass methodologies that involve biophysical chemistry, microbiology, molecular biology and bioinformatics. His research focuses on macromolecular interactions of bacterial DNA repair proteins, particularly DNA and RNA ligases, with experiments performed in vitro or in bacterial model organisms. His areas of expertise include the relationship of genetic instabilities to human diseases; trinucleotide (triplet) repeat expansions and human neurodegenerative disorders; DNA repair processes; and protein-protein and protein-DNA interactions.

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