DNA supercoiling and transcription: topological coupling of promoters

David M. J. Lilley; Dongrong Chen; Richard P. Bowater

doi:10.1017/s0033583500005825

DNA supercoiling and transcription: topological coupling of promoters

David M. J. Lilley
, Dongrong Chen
, Richard P. Bowater

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

DNA supercoiling is a consequence of the double-stranded nature of DNA. When a linear DNA molecule is ligated into a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken. The number of times one strand is linked with the other is described by a fundamental property of DNA supercoiling, the linking number (Lk).

Original language	English
Pages (from-to)	203-225
Number of pages	23
Journal	Quarterly Reviews of Biophysics
Volume	29
Issue number	3
DOIs	https://doi.org/10.1017/s0033583500005825
Publication status	Published - Aug 1996
Externally published	Yes

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title = "DNA supercoiling and transcription: topological coupling of promoters",

abstract = "DNA supercoiling is a consequence of the double-stranded nature of DNA. When a linear DNA molecule is ligated into a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken. The number of times one strand is linked with the other is described by a fundamental property of DNA supercoiling, the linking number (Lk).",

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AU - Lilley, David M. J.

AU - Chen, Dongrong

AU - Bowater, Richard P.

PY - 1996/8

Y1 - 1996/8

N2 - DNA supercoiling is a consequence of the double-stranded nature of DNA. When a linear DNA molecule is ligated into a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken. The number of times one strand is linked with the other is described by a fundamental property of DNA supercoiling, the linking number (Lk).

AB - DNA supercoiling is a consequence of the double-stranded nature of DNA. When a linear DNA molecule is ligated into a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken. The number of times one strand is linked with the other is described by a fundamental property of DNA supercoiling, the linking number (Lk).

UR - https://www.scopus.com/pages/publications/0029826454

U2 - 10.1017/s0033583500005825

DO - 10.1017/s0033583500005825

M3 - Review article

C2 - 8968111

AN - SCOPUS:0029826454

SN - 0033-5835

VL - 29

SP - 203

EP - 225

JO - Quarterly Reviews of Biophysics

JF - Quarterly Reviews of Biophysics

IS - 3

ER -

DNA supercoiling and transcription: topological coupling of promoters

Abstract

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