DNase1: No association with Crohn's disease in a New Zealand population

Angharad R. Morgan; Wen-Jiun Lam; Dug-Yeo Han; Alan G. Fraser; Lynnette R. Ferguson

doi:10.5402/2012/826323

DNase1: No association with Crohn's disease in a New Zealand population

Angharad R. Morgan, Wen-Jiun Lam, Dug-Yeo Han, Alan G. Fraser, Lynnette R. Ferguson

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.

Original language	English
Article number	826323
Journal	ISRN Gastroenterology
Volume	2012
DOIs	https://doi.org/10.5402/2012/826323
Publication status	Published - 4 Jun 2012

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10.5402/2012/826323Licence: CC BY

Cite this

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title = "DNase1: No association with Crohn's disease in a New Zealand population",

abstract = "DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.",

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AU - Lam, Wen-Jiun

AU - Han, Dug-Yeo

AU - Fraser, Alan G.

AU - Ferguson, Lynnette R.

N1 - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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N2 - DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.

AB - DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.

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