Abstract
Primary Objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury.
Research Design: A retrospective case note review assessed total rehabilitation unit admission.
Methods & Procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a United Kingdom university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.
Main Outcomes & Results: A positive change was reported in ACB results in a positive change in NPDS with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation: -6.64; SE: 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR=9.65; 95% CI: 1.36 to 68.64) and FIM-FAM Total scores (OR=0.03; 95% CI: 0.002 to 0.35).
Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.
Research Design: A retrospective case note review assessed total rehabilitation unit admission.
Methods & Procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a United Kingdom university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge.
Main Outcomes & Results: A positive change was reported in ACB results in a positive change in NPDS with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation: -6.64; SE: 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR=9.65; 95% CI: 1.36 to 68.64) and FIM-FAM Total scores (OR=0.03; 95% CI: 0.002 to 0.35).
Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.
| Original language | English |
|---|---|
| Pages (from-to) | 1426-1430 |
| Number of pages | 5 |
| Journal | Brain Injury |
| Volume | 29 |
| Issue number | 12 |
| Early online date | 5 Aug 2015 |
| DOIs | |
| Publication status | Published - Dec 2015 |
Keywords
- anticholinergic
- burden
- brain injury
- spinal cord injury
- medications
- adverse effects
- rehabilitation
Profiles
-
Jane Cross
- Dementia & Complexity in Later Life - Member
- School of Health Sciences - Associate Professor
- Lifespan Health - Member
- Volunteering and Health and Social Care - Member
- HealthUEA - Steering Committee Member
Person: Research Group Member, Academic, Teaching & Research
-
Chris Fox
- Norwich Medical School - Honorary Professor
- Institute for Volunteering Research - Member
- Norwich Epidemiology Centre - Member
- Mental Health - Member
Person: Honorary, Research Group Member, Research Centre Member
-
Toby Smith
- School of Health Sciences - Professor of Musculoskeletal Research
- Population Health - Member
- Norwich Epidemiology Centre - Member
- Health Promotion - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research