Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?

Dimitrios Polymeros; Dimitrios P Bogdanos; Richard Day; Dimitryi Arioli; Diego Vergani; Alastair Forbes

doi:10.1053/j.gastro.2006.04.021

Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?

Dimitrios Polymeros, Dimitrios P Bogdanos, Richard Day, Dimitryi Arioli, Diego Vergani, Alastair Forbes

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Most Crohn's disease (CD) patients show seroreactivity against Mycobacterium avium paratuberculosis (MAP), suggesting a pathogenic role for this organism. Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD.

Original language	English
Pages (from-to)	85-96
Number of pages	12
Journal	Gastroenterology
Volume	131
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2006.04.021
Publication status	Published - Jul 2006

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Antibody Affinity
Autoantigens
Crohn Disease
Enzyme-Linked Immunosorbent Assay
Female
Glutathione Peroxidase
Humans
Male
Middle Aged
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis
Prognosis
Severity of Illness Index

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1053/j.gastro.2006.04.021

Cite this

@article{c45be566b5464f86ba0ead01849604b0,

title = "Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?",

abstract = "Most Crohn's disease (CD) patients show seroreactivity against Mycobacterium avium paratuberculosis (MAP), suggesting a pathogenic role for this organism. Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antibody Affinity, Autoantigens, Crohn Disease, Enzyme-Linked Immunosorbent Assay, Female, Glutathione Peroxidase, Humans, Male, Middle Aged, Mycobacterium avium subsp. paratuberculosis, Paratuberculosis, Prognosis, Severity of Illness Index",

author = "Dimitrios Polymeros and Bogdanos, {Dimitrios P} and Richard Day and Dimitryi Arioli and Diego Vergani and Alastair Forbes",

year = "2006",

month = jul,

doi = "10.1053/j.gastro.2006.04.021",

language = "English",

volume = "131",

pages = "85--96",

journal = "Gastroenterology",

issn = "0016-5085",