Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?

Dimitrios Polymeros, Dimitrios P Bogdanos, Richard Day, Dimitryi Arioli, Diego Vergani, Alastair Forbes

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Most Crohn's disease (CD) patients show seroreactivity against Mycobacterium avium paratuberculosis (MAP), suggesting a pathogenic role for this organism. Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD.
Original languageEnglish
Pages (from-to)85-96
Number of pages12
JournalGastroenterology
Volume131
Issue number1
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibody Affinity
  • Autoantigens
  • Crohn Disease
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Glutathione Peroxidase
  • Humans
  • Male
  • Middle Aged
  • Mycobacterium avium subsp. paratuberculosis
  • Paratuberculosis
  • Prognosis
  • Severity of Illness Index

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