Drug Discovery and Development for Kinetoplastid Diseases

Conor R. Caffrey, Dietmar Steverding, Rafaela S. Ferreira, Renata B. de Oliveira, Anthony J. O'Donoghue, Ludovica Monti, Carlo Ballatore, Kelly A. Bachovchin, Lori Ferrins, Michael P. Pollastri, Kimberley M. Zorn, Daniel Foil, Alex M. Clark, Melina Mottin, Carolina H. Andrade, Jair L. de Siqueira-Neto, Sean Ekins

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against various protein targets, (e.g., cysteine proteases, the proteasome and tubulin), as well as cutting-edge molecular and computational strategies, and technologies being brought to bear to discover and develop new anti-trypanosomal drugs. For comprehensive descriptions of the disease, biology and drug therapies prior to 2011, the reader is encouraged to review the chapter by P. M. Woster that appeared in 2010 in the seventh edition of Burger’s Medicinal Chemistry, Drug Discovery, and Development, with the title Antiprotozoal/Antiparasitic Agents.
Original languageEnglish
Title of host publicationBurger's Medicinal Chemistry, Drug Discovery and Development
EditorsDonald J. Abraham, Michael Myers
Place of PublicationNew York
PublisherWiley
Chapter4
Pages255-344
Number of pages89
Volume7
Edition8
ISBN (Print)978-1-119-53030-5
DOIs
Publication statusE-pub ahead of print - 26 Apr 2021

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