Drug Discovery and Development for Kinetoplastid Diseases

Conor R. Caffrey; Dietmar Steverding; Rafaela S. Ferreira; Renata B. de Oliveira; Anthony J. O'Donoghue; Ludovica Monti; Carlo Ballatore; Kelly A. Bachovchin; Lori Ferrins; Michael P.  Pollastri; Kimberley M.  Zorn; Daniel Foil; Alex M.  Clark; Melina Mottin; Carolina H. Andrade; Jair L. de Siqueira-Neto; Sean Ekins

doi:10.1002/0471266949.bmc235.pub2

Drug Discovery and Development for Kinetoplastid Diseases

Conor R. Caffrey, Dietmar Steverding, Rafaela S. Ferreira, Renata B. de Oliveira, Anthony J. O'Donoghue, Ludovica Monti, Carlo Ballatore, Kelly A. Bachovchin, Lori Ferrins, Michael P. Pollastri, Kimberley M. Zorn, Daniel Foil, Alex M. Clark, Melina Mottin, Carolina H. Andrade, Jair L. de Siqueira-Neto, Sean Ekins

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against various protein targets, (e.g., cysteine proteases, the proteasome and tubulin), as well as cutting-edge molecular and computational strategies, and technologies being brought to bear to discover and develop new anti-trypanosomal drugs. For comprehensive descriptions of the disease, biology and drug therapies prior to 2011, the reader is encouraged to review the chapter by P. M. Woster that appeared in 2010 in the seventh edition of Burger’s Medicinal Chemistry, Drug Discovery, and Development, with the title Antiprotozoal/Antiparasitic Agents.

Original language	English
Title of host publication	Burger's Medicinal Chemistry, Drug Discovery and Development
Editors	Donald J. Abraham, Michael Myers
Place of Publication	New York
Publisher	Wiley
Chapter	4
Pages	255-344
Number of pages	89
Volume	7
Edition	8
ISBN (Print)	978-1-119-53030-5
DOIs	https://doi.org/10.1002/0471266949.bmc235.pub2
Publication status	Published - 26 Apr 2021

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Cite this

Caffrey, C. R., Steverding, D., Ferreira, R. S., de Oliveira, R. B., O'Donoghue, A. J., Monti, L., Ballatore, C., Bachovchin, K. A., Ferrins, L., Pollastri, M. P., Zorn, K. M., Foil, D., Clark, A. M., Mottin, M., Andrade, C. H., de Siqueira-Neto, J. L., & Ekins, S. (2021). Drug Discovery and Development for Kinetoplastid Diseases. In D. J. Abraham, & M. Myers (Eds.), Burger's Medicinal Chemistry, Drug Discovery and Development (8 ed., Vol. 7, pp. 255-344). Wiley. https://doi.org/10.1002/0471266949.bmc235.pub2

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title = "Drug Discovery and Development for Kinetoplastid Diseases",

abstract = "We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against various protein targets, (e.g., cysteine proteases, the proteasome and tubulin), as well as cutting-edge molecular and computational strategies, and technologies being brought to bear to discover and develop new anti-trypanosomal drugs. For comprehensive descriptions of the disease, biology and drug therapies prior to 2011, the reader is encouraged to review the chapter by P. M. Woster that appeared in 2010 in the seventh edition of Burger{\textquoteright}s Medicinal Chemistry, Drug Discovery, and Development, with the title Antiprotozoal/Antiparasitic Agents. ",

author = "Caffrey, {Conor R.} and Dietmar Steverding and Ferreira, {Rafaela S.} and {de Oliveira}, {Renata B.} and O'Donoghue, {Anthony J.} and Ludovica Monti and Carlo Ballatore and Bachovchin, {Kelly A.} and Lori Ferrins and Pollastri, {Michael P.} and Zorn, {Kimberley M.} and Daniel Foil and Clark, {Alex M.} and Melina Mottin and Andrade, {Carolina H.} and {de Siqueira-Neto}, {Jair L.} and Sean Ekins",

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Caffrey, CR, Steverding, D, Ferreira, RS, de Oliveira, RB, O'Donoghue, AJ, Monti, L, Ballatore, C, Bachovchin, KA, Ferrins, L, Pollastri, MP, Zorn, KM, Foil, D, Clark, AM, Mottin, M, Andrade, CH, de Siqueira-Neto, JL & Ekins, S 2021, Drug Discovery and Development for Kinetoplastid Diseases. in DJ Abraham & M Myers (eds), Burger's Medicinal Chemistry, Drug Discovery and Development. 8 edn, vol. 7, Wiley, New York, pp. 255-344. https://doi.org/10.1002/0471266949.bmc235.pub2

Drug Discovery and Development for Kinetoplastid Diseases. / Caffrey, Conor R.; Steverding, Dietmar; Ferreira, Rafaela S. et al.

Burger's Medicinal Chemistry, Drug Discovery and Development. ed. / Donald J. Abraham; Michael Myers. Vol. 7 8. ed. New York : Wiley, 2021. p. 255-344.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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AU - Caffrey, Conor R.

AU - Steverding, Dietmar

AU - Ferreira, Rafaela S.

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AU - O'Donoghue, Anthony J.

AU - Monti, Ludovica

AU - Ballatore, Carlo

AU - Bachovchin, Kelly A.

AU - Ferrins, Lori

AU - Pollastri, Michael P.

AU - Zorn, Kimberley M.

AU - Foil, Daniel

AU - Clark, Alex M.

AU - Mottin, Melina

AU - Andrade, Carolina H.

AU - de Siqueira-Neto, Jair L.

AU - Ekins, Sean

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AB - We review the disease, biology and biochemistry of kinetoplastids, as well as the new drugs and drug candidates that have entered the clinic in the last decade. We also describe examples of the pre-clinical exploration of small molecules against various protein targets, (e.g., cysteine proteases, the proteasome and tubulin), as well as cutting-edge molecular and computational strategies, and technologies being brought to bear to discover and develop new anti-trypanosomal drugs. For comprehensive descriptions of the disease, biology and drug therapies prior to 2011, the reader is encouraged to review the chapter by P. M. Woster that appeared in 2010 in the seventh edition of Burger’s Medicinal Chemistry, Drug Discovery, and Development, with the title Antiprotozoal/Antiparasitic Agents.

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BT - Burger's Medicinal Chemistry, Drug Discovery and Development

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