Dynamic susceptibility contrast-enhanced perfusion and conventional MR imaging findings for adult patients with cerebral primitive neuroectodermal tumors

Meng Law, Khuram Kazmi, Stephan Wetzel, Edwin Wang, Codrin Iacob, David Zagzag, John G. Golfinos, Glyn Johnson

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


BACKGROUND AND PURPOSE: Preoperative differentiation of primitive neuroectodermal tumors (PNETs) from other tumors is important for presurgical staging, intraoperative management, and postoperative treatment. Dynamic, susceptibility-weighted, contrast-enhanced MR imaging can provide in vivo assessment of the microvasculature in intracranial mass lesions. The purpose of this study was to determine the perfusion characteristics of adult cerebral PNETs and to compare those values with low and high grade gliomas. METHODS: Conventional MR images of 12 adult patients with pathologically proved cerebral PNETs were analyzed and provided a preoperative diagnosis. Relative cerebral blood volume (rCBV) measurements and estimates of the vascular permeability transfer constant, K(trans), derived by a pharmacokinetic modeling algorithm, were also obtained. These results were compared with rCBV and K(trans) values obtained in a group of low grade gliomas (n = 30) and a group of high grade gliomas (n = 55) by using a Student t test. RESULTS: On conventional MR images, PNETs were generally well-defined contrast-enhancing masses with solid and cystic components, little or no surrounding edema, and occasional regions of susceptibility. The rCBV of cerebral PNETs was 4.76 +/- 1.99 SD, and the K(trans) was 0.0033 +/- 0.0035. A comparative group of patients with low grade gliomas (n = 30) had significantly lower rCBV (P
Original languageEnglish
Pages (from-to)997-1005
Number of pages9
JournalAmerican Journal of Neuroradiology
Issue number6
Publication statusPublished - 2004


  • 0 (Contrast Media)
  • Adult Aged Aged
  • 80 and over Brain Neoplasms
  • Pathology
  • physiopathology Cerebrovascular Circulation Contrast Media Female Humans Magnetic Resonance Imaging
  • methods Male Middle Aged Neuroectodermal Tumors
  • Primitive
  • pathology/physiopathology

Cite this