DynDom1D_Python: An Open-Source Python tool for the analysis of domain movements in proteins

Here we introduce DynDom1D_Python, an open-source Python implementation based on the original DynDom Fortran program for the analysis of domain movements in proteins. DynDom works on a single protein chain and can be used when two structures of the same protein are available representing a conformational change. If appropriate, it describes the conformational change in terms of the relative rotation of quasi-rigid regions called "dynamic domains" by way of hinge axes (more precisely, interdomain screw axes) and hinge-bending residues (more precisely, interdomain bending residues). This new implementation improves on the original standalone version in a number of ways.