Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production

Ajay K Sinha, Stephen T Kempley, Elizabeth Price, Bal K Sharma, David M Livermore

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A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC beta-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC beta-lactamases.
Original languageEnglish
Pages (from-to)376-377
Number of pages2
JournalPediatric Infectious Disease Journal
Issue number4
Publication statusPublished - Apr 2006


  • Bacteremia
  • Bacterial Proteins
  • Cefotaxime
  • Cephalosporin Resistance
  • Enterobacteriaceae Infections
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases
  • Meningitis, Bacterial
  • Microbial Sensitivity Tests
  • Morganella morganii
  • beta-Lactamases

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