Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

C Turner, N Dalton, R Inaoui, I Fogelman, W D Fraser, G Hampson

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).
Original languageEnglish
Pages (from-to)550-556
Number of pages7
JournalThe Journal of Clinical Endocrinology and Metabolism
Issue number2
Publication statusPublished - Feb 2013


  • Aged
  • Alendronate
  • Bone Density
  • Bone Density Conservation Agents
  • Ergocalciferols
  • Female
  • Fibroblast Growth Factors
  • Humans
  • Male
  • Middle Aged
  • Osteoporosis
  • Postmenopause
  • Vitamin D
  • Vitamin D Deficiency

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