Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

C Turner; N Dalton; R Inaoui; I Fogelman; W D Fraser; G Hampson

doi:10.1210/jc.2012-2790

Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

C Turner, N Dalton, R Inaoui, I Fogelman, W D Fraser, G Hampson

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

Original language	English
Pages (from-to)	550-556
Number of pages	7
Journal	The Journal of Clinical Endocrinology and Metabolism
Volume	98
Issue number	2
DOIs	https://doi.org/10.1210/jc.2012-2790
Publication status	Published - Feb 2013

Keywords

Aged
Alendronate
Bone Density
Bone Density Conservation Agents
Ergocalciferols
Female
Fibroblast Growth Factors
Humans
Male
Middle Aged
Osteoporosis
Postmenopause
Vitamin D
Vitamin D Deficiency

Access to Document

10.1210/jc.2012-2790

Cite this

@article{54f09ab8567046b3ab9a687c6a0ca6ba,

title = "Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency",

abstract = "Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).",

keywords = "Aged, Alendronate, Bone Density, Bone Density Conservation Agents, Ergocalciferols, Female, Fibroblast Growth Factors, Humans, Male, Middle Aged, Osteoporosis, Postmenopause, Vitamin D, Vitamin D Deficiency",

author = "C Turner and N Dalton and R Inaoui and I Fogelman and Fraser, {W D} and G Hampson",

year = "2013",

month = feb,

doi = "10.1210/jc.2012-2790",

language = "English",

volume = "98",

pages = "550--556",

journal = "Journal of Clinical Endocrinology & Metabolism",

issn = "0021-972X",

publisher = "The Endocrine Society",

number = "2",

}

Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency. / Turner, C; Dalton, N; Inaoui, R et al.

In: The Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 02.2013, p. 550-556.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

AU - Turner, C

AU - Dalton, N

AU - Inaoui, R

AU - Fogelman, I

AU - Fraser, W D

AU - Hampson, G

PY - 2013/2

Y1 - 2013/2

N2 - Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

AB - Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

KW - Aged

KW - Alendronate

KW - Bone Density

KW - Bone Density Conservation Agents

KW - Ergocalciferols

KW - Female

KW - Fibroblast Growth Factors

KW - Humans

KW - Male

KW - Middle Aged

KW - Osteoporosis

KW - Postmenopause

KW - Vitamin D

KW - Vitamin D Deficiency

UR - http://www.scopus.com/inward/record.url?scp=84873623751&partnerID=8YFLogxK

U2 - 10.1210/jc.2012-2790

DO - 10.1210/jc.2012-2790

M3 - Article

C2 - 23284004

AN - SCOPUS:84873623751

VL - 98

SP - 550

EP - 556

JO - Journal of Clinical Endocrinology & Metabolism

JF - Journal of Clinical Endocrinology & Metabolism

SN - 0021-972X

IS - 2

ER -

Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

Abstract

Keywords

Access to Document

Other files and links

Cite this