Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

C Turner; N Dalton; R Inaoui; I Fogelman; W D Fraser; G Hampson

doi:10.1210/jc.2012-2790

Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

C Turner, N Dalton, R Inaoui, I Fogelman, W D Fraser, G Hampson

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

Original language	English
Pages (from-to)	550-556
Number of pages	7
Journal	The Journal of Clinical Endocrinology and Metabolism
Volume	98
Issue number	2
DOIs	https://doi.org/10.1210/jc.2012-2790
Publication status	Published - Feb 2013

Keywords

Aged
Alendronate
Bone Density
Bone Density Conservation Agents
Ergocalciferols
Female
Fibroblast Growth Factors
Humans
Male
Middle Aged
Osteoporosis
Postmenopause
Vitamin D
Vitamin D Deficiency

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10.1210/jc.2012-2790

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title = "Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency",

abstract = "Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).",

keywords = "Aged, Alendronate, Bone Density, Bone Density Conservation Agents, Ergocalciferols, Female, Fibroblast Growth Factors, Humans, Male, Middle Aged, Osteoporosis, Postmenopause, Vitamin D, Vitamin D Deficiency",

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Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency. / Turner, C; Dalton, N; Inaoui, R et al.
In: The Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 02.2013, p. 550-556.

Research output: Contribution to journal › Article › peer-review

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AU - Fraser, W D

AU - Hampson, G

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KW - Male

KW - Middle Aged

KW - Osteoporosis

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Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency

Abstract

Keywords

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