Effect of carbohydrate feeding on the bone metabolic response to running

Craig Sale, Ian Varley, Thomas W. Jones, Ruth M. James, Jonathan C. Y. Tang, William D. Fraser, Julie P. Greeves

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Abstract

PURPOSE: Bone resorption is increased following running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. To investigate the immediate and short-term bone metabolic responses to carbohydrate (CHO) feeding during treadmill running. METHODS: Ten men completed two 7 d trials, once being fed CHO (8% glucose immediately before, every 20 min during and immediately after exercise at a rate of 0.7 gCHO.kg-1BM.h-1) and once placebo (PBO). On day 4 of each trial, participants completed a 120 min treadmill run at 70% VO2max. Blood was taken at baseline (BASE) immediately after exercise (EE), after 60 (R1) and 120 (R2) min of recovery and on 3 follow-up days (FU1-FU3). Markers of bone resorption (beta-CTX) and formation (P1NP) were measured, along with OC, PTH, ACa, PO4, GLP-2, IL-6, insulin, cortisol, leptin and OPG. Area under the curve was calculated in terms of the immediate (BASE, EE, R1 and R2) and short-term (BASE, FU1, FU2 and FU3) responses to exercise. RESULTS: beta-CTX, P1NP and IL-6 responses to exercise were significantly lower in the immediate post-exercise period with CHO feeding (beta-CTX: P=0.028; P1NP: P=0.021; IL-6: P=0.036), although there was no difference in the short-term response (beta-CTX: P=0.856; P1NP: P=0.721; IL-6: P=0.327). No other variable was significantly affected by CHO feeding during exercise. CONCLUSION: CHO feeding during exercise attenuated the beta-CTX and P1NP responses in the hours but not days following exercise, indicating an acute effect of CHO feeding on bone turnover.
Original languageEnglish
Pages (from-to)824-830
Number of pages6
JournalJournal of Applied Physiology
Volume119
Issue number7
Early online date6 Aug 2015
DOIs
Publication statusPublished - 1 Oct 2015

Keywords

  • carbohydrate
  • Bone Metabolism
  • Exercise
  • feeding
  • running

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