Effect of fasting versus feeding on the bone metabolic response to running

Jonathan P R Scott, Craig Sale, Julie P Greeves, Anna Casey, John Dutton, William D Fraser

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Individuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-active males aged 28 ± 4y (mean ±SD) completed two, counterbalanced, 8d trials. After 3d on a standardised diet, participants performed 60 min of treadmill running at 65% VO(2max) on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before and during exercise, for 3h after exercise, and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for the c-terminal telopeptide region of collagen type 1 (β-CTX), n-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone alkaline phosphatase (bone ALP), parathyroid hormone (PTH), albumin-adjusted calcium, phosphate, osteoprotegerin (OPG), cortisol, leptin and ghrelin. Only the β-CTX response was significantly affected by feeding. Pre-exercise concentrations decreased more in FED compared with FAST (47% vs 26%, P
Original languageEnglish
Pages (from-to)990-9
Number of pages10
Issue number6
Publication statusPublished - Dec 2012


  • Adult
  • Bone Resorption
  • Bone and Bones
  • Fasting
  • Ghrelin
  • Humans
  • Leptin
  • Male
  • Osteocalcin
  • Parathyroid Hormone
  • Procollagen
  • Running

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