Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases

Adel Ersek; Anastasios Karadimitris; Nicole J Horwood

doi:10.3389/fendo.2012.00106

Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases

Adel Ersek, Anastasios Karadimitris, Nicole J Horwood

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.

Original language	English
Article number	106
Pages (from-to)	1-7
Journal	Frontiers in Endocrinology
Volume	3
DOIs	https://doi.org/10.3389/fendo.2012.00106
Publication status	Published - 23 Aug 2012

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Cite this

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title = "Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases",

abstract = "Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.",

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AU - Karadimitris, Anastasios

AU - Horwood, Nicole J

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AB - Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.

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DO - 10.3389/fendo.2012.00106

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JO - Frontiers in Endocrinology

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