Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases

Adel Ersek, Anastasios Karadimitris, Nicole J Horwood

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.

Original languageEnglish
Article number106
Pages (from-to)1-7
JournalFrontiers in Endocrinology
Volume3
DOIs
Publication statusPublished - 23 Aug 2012

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