Effect of L-arginine on renal blood flow in normal subjects and patients with hypoxic chronic obstructive pulmonary disease

T Q Howes, S E Keilty, V L Maskrey, C R Deane, S V Baudouin, J Moxham

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


L-arginine is the precursor of endothelium derived nitric oxide (NO) and increasing the available substrate may increase the production of NO. This has been shown by local infusion in peripheral vascular beds but there are few studies of the effects during systemic infusion. Renal vasoconstriction is known to be important in the pathogenesis of cor pulmonale in patients with hypoxic chronic obstructive pulmonary disease (COPD). The effects of a systemic infusion of L-arginine on renal and aortic haemodynamics were therefore investigated in normal subjects and in patients with hypoxic COPD.
Original languageEnglish
Pages (from-to)516-519
Number of pages4
Issue number5
Publication statusPublished - May 1996


  • Aged
  • Anoxia
  • Aorta
  • Arginine
  • Blood Flow Velocity
  • Blood Pressure
  • Case-Control Studies
  • Double-Blind Method
  • Heart Rate
  • Humans
  • Infusions, Intravenous
  • Kidney
  • Lung Diseases, Obstructive
  • Middle Aged
  • Renal Circulation
  • Ultrasonography, Doppler, Color

Cite this