Effect of polarization and chronic inflammation on macrophage expression of heparan sulfate proteoglycans and biosynthesis enzymes

Maarten Swart, Linda Troeberg

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)
28 Downloads (Pure)


Heparan sulfate (HS) proteoglycans on immune cells have the ability to bind to and regulate the bioactivity more than 400 bioactive protein ligands, including many chemokines, cytokines, and growth factors. This makes them important regulators of the phenotype and behavior of immune cells. Here we review how HS biosynthesis in macrophages is regulated during polarization and in chronic inflammatory diseases such as rheumatoid arthritis, atherosclerosis, asthma, chronic obstructive pulmonary disease and obesity, by analyzing published micro-array data and mechanistic studies in this area. We describe that macrophage expression of many HS biosynthesis and core proteins is strongly regulated by macrophage polarization, and that these expression patterns are recapitulated in chronic inflammation. Such changes in HS biosynthetic enzyme expression are likely to have a significant impact on the phenotype of macrophages in chronic inflammatory diseases by altering their interactions with chemokines, cytokines, and growth factors.

Original languageEnglish
Pages (from-to)9-27
Number of pages19
JournalJournal of Histochemistry and Cytochemistry
Issue number1
Early online date11 Sep 2018
Publication statusPublished - 1 Jan 2019


  • heparan sulfate
  • inflammation
  • macrophages
  • proteoglycans
  • rheumatoid arthritis

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