Effect of synthetic dietary triglycerides: A novel research paradigm for nutrigenomics

Linda M. Sanderson; Philip J. de Groot; Guido J. E. J. Hooiveld; Arjen Koppen; Eric Kalkhoven; Michael Müller; Sander Kersten

doi:10.1371/journal.pone.0001681

Effect of synthetic dietary triglycerides: A novel research paradigm for nutrigenomics

Linda M. Sanderson, Philip J. de Groot, Guido J. E. J. Hooiveld, Arjen Koppen, Eric Kalkhoven, Michael Müller, Sander Kersten

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo.

Original language	English
Article number	e1681
Journal	PLoS One
Volume	3
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0001681
Publication status	Published - 27 Feb 2008

Keywords

Animals
Cells, Cultured
Dietary Fats
Gene Expression Profiling
Gene Expression Regulation
Liver
PPAR alpha
Rats
Structure-Activity Relationship
Transcription Factors
Triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0001681Licence: CC BY

Cite this

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abstract = "The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo.",

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AU - Sanderson, Linda M.

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AU - Koppen, Arjen

AU - Kalkhoven, Eric

AU - Müller, Michael

AU - Kersten, Sander

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KW - Cells, Cultured

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