Effect of synthetic dietary triglycerides: A novel research paradigm for nutrigenomics

Linda M. Sanderson, Philip J. de Groot, Guido J. E. J. Hooiveld, Arjen Koppen, Eric Kalkhoven, Michael Müller, Sander Kersten

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo.
Original languageEnglish
Article numbere1681
JournalPLoS One
Issue number2
Publication statusPublished - 27 Feb 2008


  • Animals
  • Cells, Cultured
  • Dietary Fats
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Liver
  • PPAR alpha
  • Rats
  • Structure-Activity Relationship
  • Transcription Factors
  • Triglycerides

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