Effector specialization in a lineage of the Irish potato famine pathogen

Suomeng Dong; Remco Stam; Liliana M. Cano; Jing Song; Jan Sklenar; Kentaro Yoshida; Tolga O. Bozkurt; Ricardo Oliva; Zhenyu Liu; Miaoying Tian; Joe Win; Mark J. Banfield; Alexandra M E Jones; Renier A L Van Der Hoorn; Sophien Kamoun

doi:10.1126/science.1246300

Effector specialization in a lineage of the Irish potato famine pathogen

Suomeng Dong, Remco Stam, Liliana M. Cano, Jing Song, Jan Sklenar, Kentaro Yoshida, Tolga O. Bozkurt, Ricardo Oliva, Zhenyu Liu, Miaoying Tian, Joe Win, Mark J. Banfield, Alexandra M E Jones, Renier A L Van Der Hoorn, Sophien Kamoun

Research output: Contribution to journal › Article › peer-review

160 Citations (Scopus)

Abstract

Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.

Original language	English
Pages (from-to)	552-555
Number of pages	4
Journal	Science
Volume	343
Issue number	6170
DOIs	https://doi.org/10.1126/science.1246300
Publication status	Published - 2014

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10.1126/science.1246300

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title = "Effector specialization in a lineage of the Irish potato famine pathogen",

abstract = "Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.",

author = "Suomeng Dong and Remco Stam and Cano, {Liliana M.} and Jing Song and Jan Sklenar and Kentaro Yoshida and Bozkurt, {Tolga O.} and Ricardo Oliva and Zhenyu Liu and Miaoying Tian and Joe Win and Banfield, {Mark J.} and Jones, {Alexandra M E} and {Van Der Hoorn}, {Renier A L} and Sophien Kamoun",

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doi = "10.1126/science.1246300",

language = "English",

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T1 - Effector specialization in a lineage of the Irish potato famine pathogen

AU - Dong, Suomeng

AU - Stam, Remco

AU - Cano, Liliana M.

AU - Song, Jing

AU - Sklenar, Jan

AU - Yoshida, Kentaro

AU - Bozkurt, Tolga O.

AU - Oliva, Ricardo

AU - Liu, Zhenyu

AU - Tian, Miaoying

AU - Win, Joe

AU - Banfield, Mark J.

AU - Jones, Alexandra M E

AU - Van Der Hoorn, Renier A L

AU - Kamoun, Sophien

PY - 2014

Y1 - 2014

N2 - Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.

AB - Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.

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U2 - 10.1126/science.1246300

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VL - 343

SP - 552

EP - 555

JO - Science

JF - Science

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ER -

Effector specialization in a lineage of the Irish potato famine pathogen

Abstract

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Sophien Kamoun

Jan Sklenar

Joe Win

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