TY - JOUR
T1 - Effector specialization in a lineage of the Irish potato famine pathogen
AU - Dong, Suomeng
AU - Stam, Remco
AU - Cano, Liliana M.
AU - Song, Jing
AU - Sklenar, Jan
AU - Yoshida, Kentaro
AU - Bozkurt, Tolga O.
AU - Oliva, Ricardo
AU - Liu, Zhenyu
AU - Tian, Miaoying
AU - Win, Joe
AU - Banfield, Mark J.
AU - Jones, Alexandra M E
AU - Van Der Hoorn, Renier A L
AU - Kamoun, Sophien
PY - 2014
Y1 - 2014
N2 - Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.
AB - Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.
UR - http://www.scopus.com/inward/record.url?scp=84893146052&partnerID=8YFLogxK
U2 - 10.1126/science.1246300
DO - 10.1126/science.1246300
M3 - Article
C2 - 24482481
AN - SCOPUS:84893146052
SN - 0036-8075
VL - 343
SP - 552
EP - 555
JO - Science
JF - Science
IS - 6170
ER -
