Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man

Veena Kumari, Jeffrey A. Gray, Philip J. Corr, Owen F. Mulligan, Paul A. Cotter, Stuart A. Checkley

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Abstract

The effects of an indirect dopamine-agonist, d-amphetamine, and a non-selective dopamine receptor antagonist, haloperidol, were investigated in normal male volunteers using a between-subjects double-blind design in a procedural learning task, thought mainly to involve unconscious/automatic learning. The results showed: (1) d-amphetamine facilitated response speed, whereas haloperidol inhibited it, in comparison to placebo; (2) the linear increase in procedural learning corresponded with pharmacological manipulation of degree of dopaminergic activity, i.e. subjects given haloperidol showed the least, and subjects given d-amphetamine the greatest, procedural learning. The implications of these findings are discussed in relation to investigation of abnormalities of procedural learning processes in schizophrenia.
Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalPsychopharmacology
Volume129
Issue number3
DOIs
Publication statusPublished - Feb 1997

Keywords

  • Adolescent
  • Adult
  • Dextroamphetamine
  • Dopamine Agonists
  • Dopamine Antagonists
  • Haloperidol
  • Humans
  • Learning
  • Male
  • Middle Aged

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