Effects of aldosterone on forearm vasculature in treated chronic heart failure

Prasad Gunaruwan, Matthias Schmitt, James Sharman, Leong Lee, Alan Struthers, Michael Frenneaux

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.
Original languageEnglish
Pages (from-to)412-4
Number of pages3
JournalThe American Journal of Cardiology
Issue number3
Publication statusPublished - 1 Feb 2005


  • Aged
  • Aldosterone
  • Analysis of Variance
  • Blood Flow Velocity
  • Dose-Response Relationship, Drug
  • Female
  • Forearm
  • Heart Failure
  • Humans
  • Infusions, Intra-Arterial
  • Male
  • Regional Blood Flow
  • Vascular Resistance

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