Effects of aldosterone on forearm vasculature in treated chronic heart failure

Prasad Gunaruwan; Matthias Schmitt; James Sharman; Leong Lee; Alan Struthers; Michael Frenneaux

doi:10.1016/j.amjcard.2004.09.047

Effects of aldosterone on forearm vasculature in treated chronic heart failure

Prasad Gunaruwan, Matthias Schmitt, James Sharman, Leong Lee, Alan Struthers, Michael Frenneaux

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.

Original language	English
Pages (from-to)	412-4
Number of pages	3
Journal	The American Journal of Cardiology
Volume	95
Issue number	3
DOIs	https://doi.org/10.1016/j.amjcard.2004.09.047
Publication status	Published - 1 Feb 2005

Keywords

Aged
Aldosterone
Analysis of Variance
Blood Flow Velocity
Dose-Response Relationship, Drug
Female
Forearm
Heart Failure
Humans
Infusions, Intra-Arterial
Male
Regional Blood Flow
Vascular Resistance

Access to Document

10.1016/j.amjcard.2004.09.047

Cite this

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title = "Effects of aldosterone on forearm vasculature in treated chronic heart failure",

abstract = "The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.",

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T1 - Effects of aldosterone on forearm vasculature in treated chronic heart failure

AU - Gunaruwan, Prasad

AU - Schmitt, Matthias

AU - Sharman, James

AU - Lee, Leong

AU - Struthers, Alan

AU - Frenneaux, Michael

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AB - The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.

KW - Aged

KW - Aldosterone

KW - Analysis of Variance

KW - Blood Flow Velocity

KW - Dose-Response Relationship, Drug

KW - Female

KW - Forearm

KW - Heart Failure

KW - Humans

KW - Infusions, Intra-Arterial

KW - Male

KW - Regional Blood Flow

KW - Vascular Resistance

U2 - 10.1016/j.amjcard.2004.09.047

DO - 10.1016/j.amjcard.2004.09.047

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