Effects of bradykinin on venous capacitance in health and treated chronic heart failure

Prasad Gunaruwan, Abdul Maher, Lynne Williams, James Sharman, Matthias Schmitt, Ross Campbell, Michael Frenneaux

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P
Original languageEnglish
Pages (from-to)443-50
Number of pages8
JournalClinical Science
Volume116
Issue number5
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Aged
  • Aged, 80 and over
  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin-Converting Enzyme Inhibitors
  • Bradykinin
  • Bradykinin Receptor Antagonists
  • Dose-Response Relationship, Drug
  • Female
  • Forearm
  • Heart Failure
  • Humans
  • Male
  • Middle Aged
  • Receptors, Bradykinin
  • Regional Blood Flow
  • Vascular Resistance
  • Vasodilator Agents

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