Effects of bradykinin on venous capacitance in health and treated chronic heart failure

Prasad Gunaruwan; Abdul Maher; Lynne Williams; James Sharman; Matthias Schmitt; Ross Campbell; Michael Frenneaux

doi:10.1042/CS20080096

Effects of bradykinin on venous capacitance in health and treated chronic heart failure

Prasad Gunaruwan, Abdul Maher, Lynne Williams, James Sharman, Matthias Schmitt, Ross Campbell, Michael Frenneaux

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P

Original language	English
Pages (from-to)	443-50
Number of pages	8
Journal	Clinical Science
Volume	116
Issue number	5
DOIs	https://doi.org/10.1042/CS20080096
Publication status	Published - Mar 2009

Keywords

Aged
Aged, 80 and over
Angiotensin II Type 1 Receptor Blockers
Angiotensin-Converting Enzyme Inhibitors
Bradykinin
Bradykinin Receptor Antagonists
Dose-Response Relationship, Drug
Female
Forearm
Heart Failure
Humans
Male
Middle Aged
Receptors, Bradykinin
Regional Blood Flow
Vascular Resistance
Vasodilator Agents

Access to Document

10.1042/CS20080096

Cite this

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title = "Effects of bradykinin on venous capacitance in health and treated chronic heart failure",

abstract = "In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P",

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author = "Prasad Gunaruwan and Abdul Maher and Lynne Williams and James Sharman and Matthias Schmitt and Ross Campbell and Michael Frenneaux",

year = "2009",

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doi = "10.1042/CS20080096",

language = "English",

volume = "116",

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journal = "Clinical Science",

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T1 - Effects of bradykinin on venous capacitance in health and treated chronic heart failure

AU - Gunaruwan, Prasad

AU - Maher, Abdul

AU - Williams, Lynne

AU - Sharman, James

AU - Schmitt, Matthias

AU - Campbell, Ross

AU - Frenneaux, Michael

PY - 2009/3

Y1 - 2009/3

N2 - In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P

AB - In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P

KW - Aged

KW - Aged, 80 and over

KW - Angiotensin II Type 1 Receptor Blockers

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Bradykinin

KW - Bradykinin Receptor Antagonists

KW - Dose-Response Relationship, Drug

KW - Female

KW - Forearm

KW - Heart Failure

KW - Humans

KW - Male

KW - Middle Aged

KW - Receptors, Bradykinin

KW - Regional Blood Flow

KW - Vascular Resistance

KW - Vasodilator Agents

U2 - 10.1042/CS20080096

DO - 10.1042/CS20080096

M3 - Article

C2 - 18798730

VL - 116

SP - 443

EP - 450

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 5

ER -