Effects of dual therapy with corticosteroids plus long acting beta2-agonists in asthma

Graeme P. Currie, Daniel K. C. Lee, Andrew M. Wilson

Research output: Contribution to journalArticle

15 Citations (Scopus)


Asthma is a common condition characterised by inflammation, airway hyperresponsiveness and reversible airflow obstruction. Effective pharmacotherapy must therefore be aimed at attenuating these underlying hallmark features. Despite the use of regular low-to-moderate doses of inhaled corticosteroids, many patients remain symptomatic and require further 2nd line controller therapy. The addition of a concomitant long acting β2-agonist provides an effective means in which to alleviate symptoms and reduce exacerbation frequency. Moreover, both agents can be combined in a single inhaler, and provide patients with a more convenient and effective way in which to deliver treatment to the endobronchial tree. This evidenced-based review article discusses the effects of such combination inhalers upon a variety of outcome parameters and their effects upon asthmatics across a range of severities.
Original languageEnglish
Pages (from-to)683-694
Number of pages12
JournalRespiratory Medicine
Issue number6
Publication statusPublished - 2005

Cite this