Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Matthias Schmitt; Prasad Gunaruwan; Nicola Payne; Justin Taylor; Leong Lee; Andrew J M Broadley; Angus K Nightingale; John R Cockcroft; Allan D Struthers; John V Tyberg; Michael P Frenneaux

doi:10.1161/01.ATV.zhq0504.7914

Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Matthias Schmitt, Prasad Gunaruwan, Nicola Payne, Justin Taylor, Leong Lee, Andrew J M Broadley, Angus K Nightingale, John R Cockcroft, Allan D Struthers, John V Tyberg, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

Original language	English
Pages (from-to)	911-7
Number of pages	7
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1161/01.ATV.zhq0504.7914
Publication status	Published - May 2004

Keywords

Adult
Aged
Aged, 80 and over
Arteries
Atrial Natriuretic Factor
Cardiovascular Agents
Cyclic GMP
Endothelium, Vascular
Enzyme Inhibitors
Female
Forearm
Heart Failure
Humans
Injections, Intra-Arterial
Male
Middle Aged
Natriuretic Peptide, Brain
Natriuretic Peptide, C-Type
Natriuretic Peptides
Nitric Oxide
Nitric Oxide Synthase
Nitric Oxide Synthase Type III
Peptide Fragments
Tetrahydroisoquinolines
Vascular Resistance
Vasodilation
Veins
omega-N-Methylarginine

Access to Document

10.1161/01.ATV.zhq0504.7914

Cite this

Schmitt, M., Gunaruwan, P., Payne, N., Taylor, J., Lee, L., Broadley, A. J. M., Nightingale, A. K., Cockcroft, J. R., Struthers, A. D., Tyberg, J. V., & Frenneaux, M. P. (2004). Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(5), 911-7. https://doi.org/10.1161/01.ATV.zhq0504.7914

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title = "Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure",

abstract = "Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.",

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author = "Matthias Schmitt and Prasad Gunaruwan and Nicola Payne and Justin Taylor and Leong Lee and Broadley, {Andrew J M} and Nightingale, {Angus K} and Cockcroft, {John R} and Struthers, {Allan D} and Tyberg, {John V} and Frenneaux, {Michael P}",

year = "2004",

month = may,

doi = "10.1161/01.ATV.zhq0504.7914",

language = "English",

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Schmitt, M, Gunaruwan, P, Payne, N, Taylor, J, Lee, L, Broadley, AJM, Nightingale, AK, Cockcroft, JR, Struthers, AD, Tyberg, JV & Frenneaux, MP 2004, 'Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 5, pp. 911-7. https://doi.org/10.1161/01.ATV.zhq0504.7914

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AU - Schmitt, Matthias

AU - Gunaruwan, Prasad

AU - Payne, Nicola

AU - Taylor, Justin

AU - Lee, Leong

AU - Broadley, Andrew J M

AU - Nightingale, Angus K

AU - Cockcroft, John R

AU - Struthers, Allan D

AU - Tyberg, John V

AU - Frenneaux, Michael P

PY - 2004/5

Y1 - 2004/5

N2 - Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

AB - Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

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KW - Aged

KW - Aged, 80 and over

KW - Arteries

KW - Atrial Natriuretic Factor

KW - Cardiovascular Agents

KW - Cyclic GMP

KW - Endothelium, Vascular

KW - Enzyme Inhibitors

KW - Female

KW - Forearm

KW - Heart Failure

KW - Humans

KW - Injections, Intra-Arterial

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Natriuretic Peptide, C-Type

KW - Natriuretic Peptides

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Nitric Oxide Synthase Type III

KW - Peptide Fragments

KW - Tetrahydroisoquinolines

KW - Vascular Resistance

KW - Vasodilation

KW - Veins

KW - omega-N-Methylarginine

U2 - 10.1161/01.ATV.zhq0504.7914

DO - 10.1161/01.ATV.zhq0504.7914

M3 - Article

C2 - 15001459

VL - 24

SP - 911

EP - 917

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 5

ER -