Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Matthias Schmitt, Prasad Gunaruwan, Nicola Payne, Justin Taylor, Leong Lee, Andrew J M Broadley, Angus K Nightingale, John R Cockcroft, Allan D Struthers, John V Tyberg, Michael P Frenneaux

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Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.
Original languageEnglish
Pages (from-to)911-7
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number5
Publication statusPublished - May 2004


  • Adult
  • Aged
  • Aged, 80 and over
  • Arteries
  • Atrial Natriuretic Factor
  • Cardiovascular Agents
  • Cyclic GMP
  • Endothelium, Vascular
  • Enzyme Inhibitors
  • Female
  • Forearm
  • Heart Failure
  • Humans
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Natriuretic Peptides
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III
  • Peptide Fragments
  • Tetrahydroisoquinolines
  • Vascular Resistance
  • Vasodilation
  • Veins
  • omega-N-Methylarginine

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