Effects of growth hormone administration on bone mineral metabolism, PTH sensitivity and PTH secretory rhythm in postmenopausal women with established osteoporosis

Franklin Joseph, Aftab M Ahmad, Mazhar Ul-Haq, Brian H Durham, Pauline Whittingham, William Fraser, Jiten P Vora

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Growth hormone (GH) replacement improves target organ sensitivity to PTH, PTH circadian rhythm, calcium and phosphate metabolism, bone turnover, and BMD in adult GH-deficient (AGHD) patients. In postmenopausal women with established osteoporosis, GH and insulin like growth factor-1 (IGF-1) concentrations are low, and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear. We studied the effects of GH administration on PTH sensitivity, PTH circadian rhythm, and bone mineral metabolism in postmenopausal women with established osteoporosis.
Original languageEnglish
Pages (from-to)721-729
Number of pages9
JournalJournal of Bone and Mineral Research
Issue number5
Publication statusPublished - 2007

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