Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus

M Evans, R A Anderson, J C Smith, N Khan, J M Graham, A W Thomas, K Morris, D Deely, M P Frenneaux, J S Davies, A Rees

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43 Citations (Scopus)

Abstract

Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h.
Original languageEnglish
Pages (from-to)231-8
Number of pages8
JournalEuropean Journal of Clinical Investigation
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2003

Keywords

  • Adult
  • Ascorbic Acid
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Endothelium, Vascular
  • Female
  • Humans
  • Hyperlipidemias
  • Hypoglycemic Agents
  • Insulin
  • Insulin Lispro
  • Male
  • Middle Aged
  • Oxidative Stress
  • Postprandial Period

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