Abstract
Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h.
Original language | English |
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Pages (from-to) | 231-8 |
Number of pages | 8 |
Journal | European Journal of Clinical Investigation |
Volume | 33 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2003 |
Keywords
- Adult
- Ascorbic Acid
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Endothelium, Vascular
- Female
- Humans
- Hyperlipidemias
- Hypoglycemic Agents
- Insulin
- Insulin Lispro
- Male
- Middle Aged
- Oxidative Stress
- Postprandial Period