Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus

M Evans; R A Anderson; J C Smith; N Khan; J M Graham; A W Thomas; K Morris; D Deely; M P Frenneaux; J S Davies; A Rees

doi:10.1046/j.1365-2362.2003.01120.x

Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus

M Evans, R A Anderson, J C Smith, N Khan, J M Graham, A W Thomas, K Morris, D Deely, M P Frenneaux, J S Davies, A Rees

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h.

Original language	English
Pages (from-to)	231-8
Number of pages	8
Journal	European Journal of Clinical Investigation
Volume	33
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2362.2003.01120.x
Publication status	Published - Mar 2003

Keywords

Adult
Ascorbic Acid
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Endothelium, Vascular
Female
Humans
Hyperlipidemias
Hypoglycemic Agents
Insulin
Insulin Lispro
Male
Middle Aged
Oxidative Stress
Postprandial Period

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2362.2003.01120.x

Cite this

Evans, M., Anderson, R. A., Smith, J. C., Khan, N., Graham, J. M., Thomas, A. W., Morris, K., Deely, D., Frenneaux, M. P., Davies, J. S., & Rees, A. (2003). Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus. European Journal of Clinical Investigation, 33(3), 231-8. https://doi.org/10.1046/j.1365-2362.2003.01120.x

Evans, M ; Anderson, R A ; Smith, J C ; Khan, N ; Graham, J M ; Thomas, A W ; Morris, K ; Deely, D ; Frenneaux, M P ; Davies, J S ; Rees, A. / Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus. In: European Journal of Clinical Investigation. 2003 ; Vol. 33, No. 3. pp. 231-8.

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title = "Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus",

abstract = "Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h.",

keywords = "Adult, Ascorbic Acid, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Endothelium, Vascular, Female, Humans, Hyperlipidemias, Hypoglycemic Agents, Insulin, Insulin Lispro, Male, Middle Aged, Oxidative Stress, Postprandial Period",

author = "M Evans and Anderson, {R A} and Smith, {J C} and N Khan and Graham, {J M} and Thomas, {A W} and K Morris and D Deely and Frenneaux, {M P} and Davies, {J S} and A Rees",

year = "2003",

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Evans, M, Anderson, RA, Smith, JC, Khan, N, Graham, JM, Thomas, AW, Morris, K, Deely, D, Frenneaux, MP, Davies, JS & Rees, A 2003, 'Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus', European Journal of Clinical Investigation, vol. 33, no. 3, pp. 231-8. https://doi.org/10.1046/j.1365-2362.2003.01120.x

Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus. / Evans, M; Anderson, R A; Smith, J C; Khan, N; Graham, J M; Thomas, A W; Morris, K; Deely, D; Frenneaux, M P; Davies, J S; Rees, A.

In: European Journal of Clinical Investigation, Vol. 33, No. 3, 03.2003, p. 231-8.

Research output: Contribution to journal › Article › peer-review

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AU - Khan, N

AU - Graham, J M

AU - Thomas, A W

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KW - Ascorbic Acid

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KW - Diabetes Mellitus, Type 2

KW - Endothelium, Vascular

KW - Female

KW - Humans

KW - Hyperlipidemias

KW - Hypoglycemic Agents

KW - Insulin

KW - Insulin Lispro

KW - Male

KW - Middle Aged

KW - Oxidative Stress

KW - Postprandial Period

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