Efficacy and feasibility of a tele-health intervention for acute coronary syndrome patients with depression: Results of the “MoodCare” randomized controlled trial

Adrienne O’Neil, Barr Taylor, Kristy Sanderson, Sheila Cyril, Bianca Chan, Anna L. Hawkes, David L. Hare, Michael Jelinek, Kamalesh Venugopal, John J. Atherton, John Amerena, Leeanne Grigg, Darren L. Walters, Brian Oldenburg, MoodCare Investigator Team

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Purpose: We aimed to evaluate the 6-month efficacy and feasibility of a tele-health program (MoodCare) that integrates depression management into a cardiovascular disease risk reduction program for acute coronary syndrome patients with low mood.

Methods: A two-arm, parallel, randomized design was used comprising 121 patients admitted to one of six hospitals for acute coronary syndrome.

Background: Depression is common after a cardiac event, yet there remain few approaches to management that are both effective and scalable.

Results: Significant treatment effects were observed for Patient Health Questionnaire 9 (PHQ9) depression (mean difference [change] = −1.8; p = 0.025; effect size: d = 0.36) for the overall sample, when compared with usual medical care. Results were more pronounced effects for those with a history of depression (mean difference [change] = −2.7; p = 0.043; effect size: d = 0.65).

Conclusions: MoodCare was effective for improving depression in acute coronary syndrome patients, producing effect sizes exceeding those of some face-to-face psychotherapeutic interventions and pharmacotherapy. (Trial Registration Number: ACTRN1260900038623.)

Original languageEnglish
Pages (from-to)163-174
Number of pages12
JournalAnnals of Behavioral Medicine
Issue number2
Early online date26 Feb 2014
Publication statusPublished - Oct 2014


  • Acute coronary syndrome
  • Cardiac
  • Cognitive behavior therapy
  • Depression
  • Tele-health

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