Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study

Michael Mannstadt, Bart L Clarke, Tamara Vokes, Maria Luisa Brandi, Lakshminarayan Ranganath, William D Fraser, Peter Lakatos, Laszlo Bajnok, Roger Garceau, Leif Mosekilde, Hjalmar Lagast, Dolores Shoback, John P Bilezikian

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Abstract

Hypoparathyroidism results in impaired mineral homoeostasis, including hypocalcaemia and hyperphosphataemia. Treatment with high-dose oral calcium and active vitamin D does not provide adequate or consistent control of biochemical indices and can lead to serious long-term complications. We aimed to test the efficacy, safety, and tolerability of once-daily recombinant human parathyroid hormone 1-84 (rhPTH[1-84]) in adults with hypoparathyroidism.
Original languageEnglish
Pages (from-to)275-283
Number of pages9
JournalThe Lancet Diabetes & Endocrinology
Volume1
Issue number4
Early online date7 Oct 2013
DOIs
Publication statusPublished - 1 Dec 2013

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